Effect of Dietary Fiber on the Level of Free Hypoglycemic Agents in Vitro
We studied the effect of dietary fibers (DFs) on the levels of free hypoglycemic agents in vitro, i.e., glimepiride and the biguanides buformin and metformin. The levels of free buformin and free metformin were not affected by mixtures of DFs, i.e., cellulose, chitosan, pectin (PE), and glucomannan...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2022/11/01, Vol.45(11), pp.1716-1719 |
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| creator | Iwazaki, Ayano Imai, Kimie |
| description | We studied the effect of dietary fibers (DFs) on the levels of free hypoglycemic agents in vitro, i.e., glimepiride and the biguanides buformin and metformin. The levels of free buformin and free metformin were not affected by mixtures of DFs, i.e., cellulose, chitosan, pectin (PE), and glucomannan (GM), in fluids of pH 1.2 and 6.8 (similar to the pH of the stomach and intestines, respectively). However, the free biguanide level was significantly reduced by mixing with PE or sodium alginate (AL), in water. The free glimepiride level was reduced in the mixture of AL, PE, and GM (in a solution with a pH of 6.8). The changes in aqueous AL solution pH seemed to reflect the free metformin levels. Therefore, the effects of DFs on free drug levels were dependent on drug type, hypoglycemic agent, and mixing solution. In this study, the oral regimen concentrations of the drug and DFs were used. Based on these results, it is important to consider the interactions between hypoglycemic agents and DFs. |
| doi_str_mv | 10.1248/bpb.b22-00385 |
| format | Article |
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The levels of free buformin and free metformin were not affected by mixtures of DFs, i.e., cellulose, chitosan, pectin (PE), and glucomannan (GM), in fluids of pH 1.2 and 6.8 (similar to the pH of the stomach and intestines, respectively). However, the free biguanide level was significantly reduced by mixing with PE or sodium alginate (AL), in water. The free glimepiride level was reduced in the mixture of AL, PE, and GM (in a solution with a pH of 6.8). The changes in aqueous AL solution pH seemed to reflect the free metformin levels. Therefore, the effects of DFs on free drug levels were dependent on drug type, hypoglycemic agent, and mixing solution. In this study, the oral regimen concentrations of the drug and DFs were used. Based on these results, it is important to consider the interactions between hypoglycemic agents and DFs.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b22-00385</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Alginic acid ; biguanide ; Cellulose ; Chitosan ; dietary fiber ; glimepiride ; hypoglycemic agent ; Hypoglycemic agents ; interaction ; Metformin ; Pectin ; pH effects ; Sodium alginate</subject><ispartof>Biological and Pharmaceutical Bulletin, 2022/11/01, Vol.45(11), pp.1716-1719</ispartof><rights>2022 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c529t-e716bd96c9140593db0a836681f6c1b9420ae2e63608056ce4e95990263af0ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids></links><search><creatorcontrib>Iwazaki, Ayano</creatorcontrib><creatorcontrib>Imai, Kimie</creatorcontrib><title>Effect of Dietary Fiber on the Level of Free Hypoglycemic Agents in Vitro</title><title>Biological & pharmaceutical bulletin</title><description>We studied the effect of dietary fibers (DFs) on the levels of free hypoglycemic agents in vitro, i.e., glimepiride and the biguanides buformin and metformin. The levels of free buformin and free metformin were not affected by mixtures of DFs, i.e., cellulose, chitosan, pectin (PE), and glucomannan (GM), in fluids of pH 1.2 and 6.8 (similar to the pH of the stomach and intestines, respectively). However, the free biguanide level was significantly reduced by mixing with PE or sodium alginate (AL), in water. The free glimepiride level was reduced in the mixture of AL, PE, and GM (in a solution with a pH of 6.8). The changes in aqueous AL solution pH seemed to reflect the free metformin levels. Therefore, the effects of DFs on free drug levels were dependent on drug type, hypoglycemic agent, and mixing solution. In this study, the oral regimen concentrations of the drug and DFs were used. Based on these results, it is important to consider the interactions between hypoglycemic agents and DFs.</description><subject>Alginic acid</subject><subject>biguanide</subject><subject>Cellulose</subject><subject>Chitosan</subject><subject>dietary fiber</subject><subject>glimepiride</subject><subject>hypoglycemic agent</subject><subject>Hypoglycemic agents</subject><subject>interaction</subject><subject>Metformin</subject><subject>Pectin</subject><subject>pH effects</subject><subject>Sodium alginate</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp90D1PwzAQgGELgUT5GNktsbCknD9jjwgoRarEAqyW415KqjQptovUf09KUQcGFnu45yzrJeSKwZhxaW6rdTWuOC8AhFFHZMSELAvFmTomI7DMFJopc0rOUloCQAlcjMjzY11jyLSv6UOD2cctnTQVRtp3NH8gneEXtrvpJCLS6XbdL9ptwFUT6N0Cu5xo09H3Jsf-gpzUvk14-Xufk7fJ4-v9tJi9PD3f382KoLjNBZZMV3Org2USlBXzCrwRWhtW68AqKzl45KiFBgNKB5RolbXAtfA1VF6ck5v9u-vYf24wZbdqUsC29R32m-R4KbgS1kg50Os_dNlvYjf8blBKKmU4lP8rwThX1qhBFXsVYp9SxNqtY7MaejkGbpffDfndkN_95B_8w94vU_YLPGgfcxNa_NFSOcZ252HtMA4fPjrsxDd--4zF</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Iwazaki, Ayano</creator><creator>Imai, Kimie</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20221101</creationdate><title>Effect of Dietary Fiber on the Level of Free Hypoglycemic Agents in Vitro</title><author>Iwazaki, Ayano ; Imai, Kimie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-e716bd96c9140593db0a836681f6c1b9420ae2e63608056ce4e95990263af0ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alginic acid</topic><topic>biguanide</topic><topic>Cellulose</topic><topic>Chitosan</topic><topic>dietary fiber</topic><topic>glimepiride</topic><topic>hypoglycemic agent</topic><topic>Hypoglycemic agents</topic><topic>interaction</topic><topic>Metformin</topic><topic>Pectin</topic><topic>pH effects</topic><topic>Sodium alginate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwazaki, Ayano</creatorcontrib><creatorcontrib>Imai, Kimie</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwazaki, Ayano</au><au>Imai, Kimie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Dietary Fiber on the Level of Free Hypoglycemic Agents in Vitro</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><date>2022-11-01</date><risdate>2022</risdate><volume>45</volume><issue>11</issue><spage>1716</spage><epage>1719</epage><pages>1716-1719</pages><artnum>b22-00385</artnum><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We studied the effect of dietary fibers (DFs) on the levels of free hypoglycemic agents in vitro, i.e., glimepiride and the biguanides buformin and metformin. The levels of free buformin and free metformin were not affected by mixtures of DFs, i.e., cellulose, chitosan, pectin (PE), and glucomannan (GM), in fluids of pH 1.2 and 6.8 (similar to the pH of the stomach and intestines, respectively). However, the free biguanide level was significantly reduced by mixing with PE or sodium alginate (AL), in water. The free glimepiride level was reduced in the mixture of AL, PE, and GM (in a solution with a pH of 6.8). The changes in aqueous AL solution pH seemed to reflect the free metformin levels. Therefore, the effects of DFs on free drug levels were dependent on drug type, hypoglycemic agent, and mixing solution. In this study, the oral regimen concentrations of the drug and DFs were used. Based on these results, it is important to consider the interactions between hypoglycemic agents and DFs.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><doi>10.1248/bpb.b22-00385</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alginic acid biguanide Cellulose Chitosan dietary fiber glimepiride hypoglycemic agent Hypoglycemic agents interaction Metformin Pectin pH effects Sodium alginate |
| title | Effect of Dietary Fiber on the Level of Free Hypoglycemic Agents in Vitro |
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