IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer

Extensive infiltration of tumor-associated macrophages was correlated poor prognosis in anaplastic thyroid cancer (ATC). However, the heterogeneity and characteristics of the ATC-associated macrophages (ATAMs) in ATC remain far from clear. We combined single-cell RNA-sequencing analysis and gene exp...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2023-01, Vol.1869 (1), p.166591-166591, Article 166591
Hauptverfasser:	Pan, Zongfu, Bao, Lisha, Lu, Xixuan, Hu, Xiaoping, Li, Lu, Chen, Jinming, Jin, Tiefeng, Zhang, Yiwen, Tan, Zhuo, Huang, Ping, Ge, Minghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic thyroid cancer CD8-Positive T-Lymphocytes Heterogeneity Humans Immune escape Interleukin-2 Receptor alpha Subunit Macrophage Macrophages Single-cell RNA-sequencing Thyroid Carcinoma, Anaplastic - genetics Thyroid Neoplasms - genetics Tumor Microenvironment Tumor-Associated Macrophages
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