Salidroside alleviates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis‐associated Th17/Treg imbalance

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by flora disequilibrium and mucosal immunity disorder. Here, we report that salidroside effectively restricts experimental colitis from two aspects of intestinal macrophage pyroptosis and dysbacteriosis‐derived colonic Th1...

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Veröffentlicht in:	Phytotherapy research 2023-02, Vol.37 (2), p.367-382
Hauptverfasser:	Liu, Xiaoman, Zhou, Mingxia, Dai, Zhenzhen, Luo, Shangjian, Shi, Yingying, He, Zhenjuan, Chen, Yingwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Bone marrow Caspase Colitis - chemically induced Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Dextran Sulfate - adverse effects Digestive system Dysbacteriosis Dysbiosis Flora Gastrointestinal tract gut microbiota Helper cells IBD Immune clearance Immunity Inflammation - metabolism Inflammatory bowel disease Inflammatory bowel diseases Innate immunity Intestinal microflora Lymphocytes T Macrophages Macrophages - metabolism Mice Mice, Inbred C57BL Mucosal immunity NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Proteins Pyroptosis Salidroside T-Lymphocytes, Regulatory - metabolism TREM1 signalling Triggering Receptor Expressed on Myeloid Cells-1 - metabolism Ulcerative colitis
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