Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B

ICH S7B recommends screening for hERG channel block using patch clamp recordings to assess a drug's proarrhythmic risk. Block of the hERG channel has been associated with clinical QTC prolongation as well as the rare, but potentially fatal ventricular tachyarrhythmia Torsade de Pointes (TdP). D...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2022-11, Vol.118, p.107229-107229, Article 107229
Hauptverfasser:	King, Tamara I., Indapurkar, Amruta, Tariq, Isra, DePalma, Ryan, Mistry, Sabyasachy, Alvarez-Baron, Claudia, Ismaiel, Omnia A., Wu, Wendy, Chiu, Kimberly, Patel, Vikram, Rouse, Rodney, Strauss, David G., Matta, Murali K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioanalytical methods Cardiac safety Concentration verification Drug loss hERG assay Nonspecific binding Positive controls UPLC-MS/MS
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