Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

Hypertension is one of the leading causes of chronic kidney disease characterized with renal fibrosis. This study aimed to investigate roles and mechanisms of sirtuin 7 (SIRT7) in hypertensive renal injury. Mini-pumps were implanted to male C57BL/6 mice to deliver angiotensin (Ang) Ⅱ (1.5 mg/kg/d) o...

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Veröffentlicht in:	Free radical biology & medicine 2022-11, Vol.193 (Pt 1), p.459-473
Hauptverfasser:	Li, Xue-Ting, Song, Jia-Wei, Zhang, Zhen-Zhou, Zhang, Mi-Wen, Liang, Li-Rong, Miao, Ran, Liu, Ying, Chen, Yi-Hang, Liu, Xiao-Yan, Zhong, Jiu-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Epithelial-mesenchymal transition Ferroptosis Ferroptosis - genetics Fibrosis Hypertension Hypertension - metabolism Kidney - metabolism Kidney Diseases - genetics Kidney Diseases - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Male Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Renal fibrosis Sirtuin 7 Sirtuins - genetics Sirtuins - metabolism
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