Comprehensive analysis of human IL‐4 receptor subunits shows compartmentalization in steady state and dupilumab treatment

Background Insight into the pathomechanism of atopic diseases demonstrated a pivotal role of the cytokines interleukin‐4 (IL‐4) and IL‐13, which has spurred the development of tailored therapeutics targeting their common IL‐4 receptor (IL‐4R). However, several aspects of the IL‐4R system remain ill‐...

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Veröffentlicht in:	Allergy (Copenhagen) 2023-04, Vol.78 (4), p.1073-1087
Hauptverfasser:	Heeb, Lukas E. M., Boyman, Onur
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Atopy B-Lymphocytes - metabolism cytokine receptors Drug development Flow cytometry Gene expression Humans interleukin‐4 Internalization Intracellular Leukocytes (neutrophilic) Lymphocytes B Monoclonal antibodies mRNA patients Proteins Receptors, Interleukin-4 - metabolism RNA, Messenger - analysis
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