Cholesterol-binding sequence is a key regulatory motif of cellular folding and conformational activation for C-reactive protein

Human, rat, and mouse C-reactive protein (CRP) possess distinct expression patterns, but have similar conformations and conserved in vivo functions. We have previously demonstrated that this level-function mismatch is delicately tuned by the hidden activities of unfolded CRP. The cholesterol-binding...

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Veröffentlicht in:	Molecular immunology 2022-12, Vol.152, p.123-128
Hauptverfasser:	Lv, Jian-Min, Huang, Xiao-Ping, Chen, Jun-Yao, Cheng, Bin, Chen, Wen-Zhuo, Yuan, Ping, Wu, Feng, Li, Hai-Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	C-reactive protein Cellular folding Cholesterol-binding sequence Conformational activation Regulatory motif
Online-Zugang:	Volltext
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