A tetravalent peptide that binds to the RANK-binding region of TRAF6 via a multivalent interaction efficiently inhibits osteoclast differentiation

Inhibition of osteoclast differentiation is a promising approach for the treatment of osteoporosis and rheumatoid arthritis. Receptor activator of nuclear factor kappa B (NF-κB) (RANK), which is an essential molecule for osteoclast differentiation, interacts with tumor necrosis factor (TNF) receptor...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-12, Vol.636 (Pt 1), p.178-183
Hauptverfasser:	Anzai, Masataka, Watanabe-Takahashi, Miho, Kawabata, Hiroshi, Mizuno, Saori, Taguchi, Yuu, Inoue, Jun-ichiro, Nishikawa, Kiyotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - physiology Multivalent interaction NF-kappa B - metabolism Osteoclast differentiation Osteoclasts - metabolism Peptides - metabolism Peptides - pharmacology RANK RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - metabolism Tetravalent peptide TNF Receptor-Associated Factor 6 - metabolism TRAF6
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