Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin
We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expressi...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2022-10, Vol.173 (6), p.760-764 |
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| creator | Hasan, A. A. Sh Kalinina, E. V. Tatarskiy, V. V. Volodina, Yu. L. Petrova, А. S. Novichkova, M. D. Zhdanov, D. D. Shtil, A. A. |
| description | We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expression of genes encoding the key antioxidant enzymes (
SOD2
,
CAT
,
GPX1
, and
HO-1
), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells. |
| doi_str_mv | 10.1007/s10517-022-05626-9 |
| format | Article |
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SOD2
,
CAT
,
GPX1
, and
HO-1
), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-022-05626-9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>1-Phosphatidylinositol 3-kinase ; Adenocarcinoma ; AKT protein ; Antioxidants ; Antitumor agents ; Apoptosis ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer cells ; Cell Biology ; Cell cycle ; Cell viability ; Chemotherapy ; Cisplatin ; Drug resistance ; Enzymes ; Flavonoids ; Free radicals ; Gene expression ; Genes ; Internal Medicine ; Kinases ; Laboratory Medicine ; Ovaries ; Pathology ; Quercetin ; Signal transduction ; Software ; TOR protein</subject><ispartof>Bulletin of experimental biology and medicine, 2022-10, Vol.173 (6), p.760-764</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-492a3d14c974bd77ca1c91ff03e7dc2274e09fdc700a211ed1da1d944802c1923</citedby><cites>FETCH-LOGICAL-c450t-492a3d14c974bd77ca1c91ff03e7dc2274e09fdc700a211ed1da1d944802c1923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-022-05626-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-022-05626-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Hasan, A. A. Sh</creatorcontrib><creatorcontrib>Kalinina, E. V.</creatorcontrib><creatorcontrib>Tatarskiy, V. V.</creatorcontrib><creatorcontrib>Volodina, Yu. L.</creatorcontrib><creatorcontrib>Petrova, А. S.</creatorcontrib><creatorcontrib>Novichkova, M. D.</creatorcontrib><creatorcontrib>Zhdanov, D. D.</creatorcontrib><creatorcontrib>Shtil, A. A.</creatorcontrib><title>Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expression of genes encoding the key antioxidant enzymes (
SOD2
,
CAT
,
GPX1
, and
HO-1
), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Adenocarcinoma</subject><subject>AKT protein</subject><subject>Antioxidants</subject><subject>Antitumor agents</subject><subject>Apoptosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cell Biology</subject><subject>Cell cycle</subject><subject>Cell viability</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Drug resistance</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Laboratory Medicine</subject><subject>Ovaries</subject><subject>Pathology</subject><subject>Quercetin</subject><subject>Signal transduction</subject><subject>Software</subject><subject>TOR protein</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kl1rFDEUhgdRcK3-Aa8Cgngz3XzNZnK5DFaLhdZuvQ5pcmY3dSYZkwy6_nqzXaFWRHIREp73IYe8VfWa4FOCsVgmghsiakxpjZsVXdXySbUgjWB1Syl5Wi1woWretu3z6kVKd4cjXpFF9XMzT1OElFzwKPQo7wCtfXbhh7PaZ7TZpwwj0t6iq3P2abn-mpfjzeU12rit14PzW3Sl8-673iPnUefSNOjsfH0NyaV8MHTaG4iog2FI6HaPPs8QDRTmZfWs10OCV7_3k-rL2fub7mN9cfnhvFtf1IY3ONdcUs0s4UYKfmuFMJoYSfoeMxDWUCo4YNlbIzDWlBCwxGpiJectpoZIyk6qd0fvFMO3GVJWo0umPEd7CHNSVDDCi4bggr75C70Lcyxz3lOsbYpPPFBbPYByvg85anOQqrVgq0YyLttCnf6DKsvC6Ezw0Lty_yjw9o_ADvSQdykMc_kMnx6D9AiaGFKK0KspulHHvSJYHeqgjnVQpQ7qvg5KlhA7hlKB_Rbiw2j_Sf0CCtO1Sg</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Hasan, A. 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Sh ; Kalinina, E. V. ; Tatarskiy, V. V. ; Volodina, Yu. L. ; Petrova, А. S. ; Novichkova, M. D. ; Zhdanov, D. D. ; Shtil, A. 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A. Sh</creatorcontrib><creatorcontrib>Kalinina, E. V.</creatorcontrib><creatorcontrib>Tatarskiy, V. V.</creatorcontrib><creatorcontrib>Volodina, Yu. L.</creatorcontrib><creatorcontrib>Petrova, А. S.</creatorcontrib><creatorcontrib>Novichkova, M. D.</creatorcontrib><creatorcontrib>Zhdanov, D. D.</creatorcontrib><creatorcontrib>Shtil, A. 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A. Sh</au><au>Kalinina, E. V.</au><au>Tatarskiy, V. V.</au><au>Volodina, Yu. L.</au><au>Petrova, А. S.</au><au>Novichkova, M. D.</au><au>Zhdanov, D. D.</au><au>Shtil, A. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>173</volume><issue>6</issue><spage>760</spage><epage>764</epage><pages>760-764</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expression of genes encoding the key antioxidant enzymes (
SOD2
,
CAT
,
GPX1
, and
HO-1
), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10517-022-05626-9</doi><tpages>5</tpages></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase Adenocarcinoma AKT protein Antioxidants Antitumor agents Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cell Biology Cell cycle Cell viability Chemotherapy Cisplatin Drug resistance Enzymes Flavonoids Free radicals Gene expression Genes Internal Medicine Kinases Laboratory Medicine Ovaries Pathology Quercetin Signal transduction Software TOR protein |
| title | Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin |
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