Selpercatinib Receives Regular Approval for Non–Small Cell Lung Cancer

Selpercatinib was granted regular approval from the US FDA to treat adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a rearranged during transfection (RET) gene fusion, as detected by an FDA-approved test. A companion diagnostic test also was approved. Marketed as R...

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2022-11, Vol.328 (17), p.1679-1679
1. Verfasser: Larkin, Howard D
Format: Artikel
Sprache:eng
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Zusammenfassung:Selpercatinib was granted regular approval from the US FDA to treat adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a rearranged during transfection (RET) gene fusion, as detected by an FDA-approved test. A companion diagnostic test also was approved. Marketed as Retevmo by Eli Lilly, selpercatinib is potent against a variety of cancer-causing RET protein alterations, including gene fusions. RET gene fusions drive 1% to 2% of NSCLCs and are responsible for an estimated 10,000 new cases annually worldwide. RET fusions are also found in 10% to 20% of papillary thyroid cancers as well as subgroups of colorectal, breast, and other cancers.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2022.18445