Targeting Parallel Topology of G‑Quadruplex Structures by Indole- Fused Quindoline Scaffolds

Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three indole-fused quindoline derivatives with varying lengths of side chains (InqEt1, InqEt2, and InqPr2) as s...

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Veröffentlicht in:	Biochemistry (Easton) 2022-11, Vol.61 (22), p.2546-2559
Hauptverfasser:	Kumar, Satendra, Pany, Sushree Prangya Priyadarshinee, Sudhakar, Sruthi, Singh, Sushma B., Todankar, Chaitra S., Pradeepkumar, P. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	G-Quadruplexes Indoles - chemistry Ligands Quinolines
Online-Zugang:	Volltext
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