Allogeneic and xenogeneic lymphoid reconstitution in a RAG2 -/- IL2RG y /- severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems. To address these limitations, we generated immunodeficient pigs and demonstrate successful engraftme...

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Veröffentlicht in:	Frontiers in veterinary science 2022, Vol.9, p.965316-965316
Hauptverfasser:	Sper, Renan B, Proctor, Jessica, Lascina, Odessa, Guo, Ling, Polkoff, Kathryn, Kaeser, Tobias, Simpson, Sean, Borst, Luke, Gleason, Katherine, Zhang, Xia, Collins, Bruce, Murphy, Yanet, Platt, Jeffrey L, Piedrahita, Jorge A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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