Structural Properties of Hachimoji Nucleic Acids and Their Building Blocks: Comparison of Genetic Systems with Four, Six and Eight Alphabets

Expansion of the genetic alphabet is an ambitious goal. A recent breakthrough has led to the eight‐base (hachimoji) genetics having canonical and unnatural bases. However, very little is known on the molecular‐level features that facilitate the candidature of unnatural bases as genetic alphabets. He...

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