Design, synthesis and antitumor activity evaluation of novel indole acrylamide derivatives as IMPDH inhibitors

[Display omitted] •Thirty-seven novel indole acrylamide derivatives were synthesized as hIMPDH2 inhibitors.•It was confirmed that the introduction of cyano group at the 3-position of indole was more favorable than dihydrothiazolyl group for the inhibitory activity of hIMPDH2.•Compounds 14e and 14n,...

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Veröffentlicht in:	Bioorganic chemistry 2022-12, Vol.129, p.106213-106213, Article 106213
Hauptverfasser:	Jia, Hong-Wei, Yang, Hua-Li, Xiong, Zhi-Ling, Deng, Ming-Hui, Wang, Tong, Liu, Yang, Cheng, Maosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide - pharmacology Antineoplastic Agents - pharmacology Antitumor Enzyme Inhibitors - pharmacology Humans IMP Dehydrogenase IMPDH Indole acrylamide derivatives Indoles - pharmacology
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