Glucagon induces the hepatic expression of inflammatory markers in vitro and in vivo

Glucagon exerts multiple hepatic actions, including stimulation of glycogenolysis/gluconeogenesis. The liver plays a crucial role in chronic inflammation by synthesizing proinflammatory molecules, which are thought to contribute to insulin resistance and hyperglycaemia. Whether glucagon affects hepa...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2023-02, Vol.25 (2), p.556-569
Hauptverfasser:	Andreozzi, Francesco, Di Fatta, Concetta, Spiga, Rosangela, Mannino, Gaia Chiara, Mancuso, Elettra, Averta, Carolina, De Caro, Carmen, Tallarico, Martina, Leo, Antonio, Citraro, Rita, Russo, Emilio, De Sarro, Giovambattista, Sesti, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase Complement C3 - pharmacology cytokines Diabetes mellitus Fibrinogen Glucagon Glucagon - pharmacology Gluconeogenesis Hyperglycemia Inflammasomes Inflammasomes - metabolism Inflammation Insulin Insulin resistance Interleukin 6 Interleukin-1beta - metabolism Interleukin-1beta - pharmacology Liver Liver - metabolism liver inflammation low‐grade inflammation Mice NF-kappa B - metabolism NF-kappa B - pharmacology NF‐κB pathway NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Phosphorylation Signal Transduction Stat3 protein TRAF2 protein
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