Ligand recognition and allosteric modulation of the human MRGPRX1 receptor

The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter primary sensory neurons and involved in the mediation of nociception and pruritus. Central activation of MRGPRX1 by the endogenous opioid peptide fragment BAM8-22 and its positive alloster...

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Veröffentlicht in:	Nature chemical biology 2023-04, Vol.19 (4), p.416-422
Hauptverfasser:	Liu, Yongfeng, Cao, Can, Huang, Xi-Ping, Gumpper, Ryan H., Rachman, Moira M., Shih, Sheng-Luen, Krumm, Brian E., Zhang, Shicheng, Shoichet, Brian K., Fay, Jonathan F., Roth, Bryan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2258 631/80/86 631/92/612/194 631/92/613 Agonists Allosteric properties Allosteric Regulation Allosteric Site Analgesics Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Drug development Electron microscopy Humans Ligands Modulation Narcotics Opioid receptors Pain Pain perception Pruritus Receptors Receptors, G-Protein-Coupled - metabolism Sensory neurons
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