Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice
Black tea is one of the six major tea categories and has a variety of bioactivities. However, little is known about its comprehensive evaluation of hypoglycemic effects and potential mechanisms. In this study, we investigated the in vivo hypoglycemic activity and potential mechanism for aqueous extr...
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| Veröffentlicht in: | Plant foods for human nutrition (Dordrecht) 2023-03, Vol.78 (1), p.61-67 |
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| creator | Shang, Lutong Li, Fanglan Zhu, Jiangxiong Sun, Chuanwen Wang, Yuanfeng |
| description | Black tea is one of the six major tea categories and has a variety of bioactivities. However, little is known about its comprehensive evaluation of hypoglycemic effects and potential mechanisms. In this study, we investigated the
in vivo
hypoglycemic activity and potential mechanism for aqueous extracts of ordinary black tea (BT) and selenium-enriched black tea (Se-BT) by using an established high-fat diet together with streptozotocin (STZ)-induced hyperglycemic mouse model. Additionally, we also explored their
α
-glucosidase inhibition activity. The results show that both BT and Se-BT had a favorable glycosidase inhibitory activity. Moreover, the intervention of BT and Se-BT could regulate the mRNA expression and the level of serum parameters related to glucose and lipid metabolisms. Accordingly, they could activate the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathway and alleviate insulin resistance (IR) and hyperglycemia. Moreover, supplementation of BT and Se-BT increased the richness and diversity of intestinal flora and altered the abundance of beneficial and harmful bacteria. Both BT and Se-BT could regulate glucose metabolism, alleviate tissue damage, and restore intestinal flora dysbiosis, suggesting that they could be used as a natural functional food for preventing hyperglycemia. |
| doi_str_mv | 10.1007/s11130-022-01022-w |
| format | Article |
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in vivo
hypoglycemic activity and potential mechanism for aqueous extracts of ordinary black tea (BT) and selenium-enriched black tea (Se-BT) by using an established high-fat diet together with streptozotocin (STZ)-induced hyperglycemic mouse model. Additionally, we also explored their
α
-glucosidase inhibition activity. The results show that both BT and Se-BT had a favorable glycosidase inhibitory activity. Moreover, the intervention of BT and Se-BT could regulate the mRNA expression and the level of serum parameters related to glucose and lipid metabolisms. Accordingly, they could activate the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathway and alleviate insulin resistance (IR) and hyperglycemia. Moreover, supplementation of BT and Se-BT increased the richness and diversity of intestinal flora and altered the abundance of beneficial and harmful bacteria. Both BT and Se-BT could regulate glucose metabolism, alleviate tissue damage, and restore intestinal flora dysbiosis, suggesting that they could be used as a natural functional food for preventing hyperglycemia.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1007/s11130-022-01022-w</identifier><identifier>PMID: 36308615</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Animals ; Black tea ; Blood Glucose - metabolism ; Camellia sinensis - metabolism ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Dysbacteriosis ; Ecology ; Flora ; Food Science ; Functional foods & nutraceuticals ; Gastrointestinal Microbiome ; Gene expression ; Glucose ; Glucose metabolism ; Glucosidase ; Glycosidases ; High fat diet ; Hyperglycemia ; Hypoglycemic Agents - pharmacology ; In vivo methods and tests ; Insulin ; Insulin resistance ; Intestinal microflora ; Intestine ; Kinases ; Lipid metabolism ; Lipids ; Metabolism ; Mice ; Mice, Obese ; Nutrition ; Phosphatidylinositol 3-Kinases - metabolism ; Plant Physiology ; Selenium ; Signal transduction ; Streptozocin ; Tea ; α-Glucosidase</subject><ispartof>Plant foods for human nutrition (Dordrecht), 2023-03, Vol.78 (1), p.61-67</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-619a7d0c6ef26e4578a575eb9f0bbace0841e3d0a6692e583cf02c22e6e8f283</citedby><cites>FETCH-LOGICAL-c305t-619a7d0c6ef26e4578a575eb9f0bbace0841e3d0a6692e583cf02c22e6e8f283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11130-022-01022-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11130-022-01022-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36308615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shang, Lutong</creatorcontrib><creatorcontrib>Li, Fanglan</creatorcontrib><creatorcontrib>Zhu, Jiangxiong</creatorcontrib><creatorcontrib>Sun, Chuanwen</creatorcontrib><creatorcontrib>Wang, Yuanfeng</creatorcontrib><title>Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice</title><title>Plant foods for human nutrition (Dordrecht)</title><addtitle>Plant Foods Hum Nutr</addtitle><addtitle>Plant Foods Hum Nutr</addtitle><description>Black tea is one of the six major tea categories and has a variety of bioactivities. However, little is known about its comprehensive evaluation of hypoglycemic effects and potential mechanisms. In this study, we investigated the
in vivo
hypoglycemic activity and potential mechanism for aqueous extracts of ordinary black tea (BT) and selenium-enriched black tea (Se-BT) by using an established high-fat diet together with streptozotocin (STZ)-induced hyperglycemic mouse model. Additionally, we also explored their
α
-glucosidase inhibition activity. The results show that both BT and Se-BT had a favorable glycosidase inhibitory activity. Moreover, the intervention of BT and Se-BT could regulate the mRNA expression and the level of serum parameters related to glucose and lipid metabolisms. Accordingly, they could activate the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathway and alleviate insulin resistance (IR) and hyperglycemia. Moreover, supplementation of BT and Se-BT increased the richness and diversity of intestinal flora and altered the abundance of beneficial and harmful bacteria. Both BT and Se-BT could regulate glucose metabolism, alleviate tissue damage, and restore intestinal flora dysbiosis, suggesting that they could be used as a natural functional food for preventing hyperglycemia.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Animals</subject><subject>Black tea</subject><subject>Blood Glucose - metabolism</subject><subject>Camellia sinensis - metabolism</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Dysbacteriosis</subject><subject>Ecology</subject><subject>Flora</subject><subject>Food Science</subject><subject>Functional foods & nutraceuticals</subject><subject>Gastrointestinal Microbiome</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucosidase</subject><subject>Glycosidases</subject><subject>High fat diet</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>In vivo methods and tests</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Kinases</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Obese</subject><subject>Nutrition</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Plant Physiology</subject><subject>Selenium</subject><subject>Signal transduction</subject><subject>Streptozocin</subject><subject>Tea</subject><subject>α-Glucosidase</subject><issn>0921-9668</issn><issn>1573-9104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFP2zAYhq2JaXRsf2AHZIkLl2yf7caJj1ABRSpC2nq3HOdLMThJsROhHvnncxvGpB12sQ9-3sef_RLyjcF3BlD8iIwxARlwngHbry8fyIzlhcgUg_kRmYHiLFNSlsfkc4yPkEJS5p_IsZACSsnyGXn9hR47N7bZVRecfcCamq6m96F2nQk7eumNfaJrNJH-xM3ozYB0eEB6h4Opeu9iS_uG3vjR9hEP0ZXbukly2w0Yh-Tx9Nr3wezJ5W6LYeN3Fltn6Z2z-IV8bIyP-PVtPyHr66v1Ypmt7m9uFxerzArIh0wyZYoarMSGS5znRWnyIsdKNVBVxiKUc4aiBiOl4piXwjbALecosWx4KU7I-aTdhv55THPp1kWL3psO-zFqXggQTHAhEnr2D_rYjyE9Y08Vis1BKZUoPlE29DEGbPQ2uDb9mWag9_3oqR-dmtGHfvRLCp2-qceqxfo98qeQBIgJiOmo22D4e_d_tL8Bq2Cbtw</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Shang, Lutong</creator><creator>Li, Fanglan</creator><creator>Zhu, Jiangxiong</creator><creator>Sun, Chuanwen</creator><creator>Wang, Yuanfeng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230301</creationdate><title>Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice</title><author>Shang, Lutong ; Li, Fanglan ; Zhu, Jiangxiong ; Sun, Chuanwen ; Wang, Yuanfeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-619a7d0c6ef26e4578a575eb9f0bbace0841e3d0a6692e583cf02c22e6e8f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Animals</topic><topic>Black tea</topic><topic>Blood Glucose - metabolism</topic><topic>Camellia sinensis - metabolism</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Dysbacteriosis</topic><topic>Ecology</topic><topic>Flora</topic><topic>Food Science</topic><topic>Functional foods & nutraceuticals</topic><topic>Gastrointestinal Microbiome</topic><topic>Gene expression</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glucosidase</topic><topic>Glycosidases</topic><topic>High fat diet</topic><topic>Hyperglycemia</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>In vivo methods and tests</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Kinases</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Obese</topic><topic>Nutrition</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Plant Physiology</topic><topic>Selenium</topic><topic>Signal transduction</topic><topic>Streptozocin</topic><topic>Tea</topic><topic>α-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shang, Lutong</creatorcontrib><creatorcontrib>Li, Fanglan</creatorcontrib><creatorcontrib>Zhu, Jiangxiong</creatorcontrib><creatorcontrib>Sun, Chuanwen</creatorcontrib><creatorcontrib>Wang, Yuanfeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shang, Lutong</au><au>Li, Fanglan</au><au>Zhu, Jiangxiong</au><au>Sun, Chuanwen</au><au>Wang, Yuanfeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><stitle>Plant Foods Hum Nutr</stitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>78</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>Black tea is one of the six major tea categories and has a variety of bioactivities. However, little is known about its comprehensive evaluation of hypoglycemic effects and potential mechanisms. In this study, we investigated the
in vivo
hypoglycemic activity and potential mechanism for aqueous extracts of ordinary black tea (BT) and selenium-enriched black tea (Se-BT) by using an established high-fat diet together with streptozotocin (STZ)-induced hyperglycemic mouse model. Additionally, we also explored their
α
-glucosidase inhibition activity. The results show that both BT and Se-BT had a favorable glycosidase inhibitory activity. Moreover, the intervention of BT and Se-BT could regulate the mRNA expression and the level of serum parameters related to glucose and lipid metabolisms. Accordingly, they could activate the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathway and alleviate insulin resistance (IR) and hyperglycemia. Moreover, supplementation of BT and Se-BT increased the richness and diversity of intestinal flora and altered the abundance of beneficial and harmful bacteria. Both BT and Se-BT could regulate glucose metabolism, alleviate tissue damage, and restore intestinal flora dysbiosis, suggesting that they could be used as a natural functional food for preventing hyperglycemia.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36308615</pmid><doi>10.1007/s11130-022-01022-w</doi><tpages>7</tpages></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Animals Black tea Blood Glucose - metabolism Camellia sinensis - metabolism Chemistry Chemistry and Materials Science Chemistry/Food Science Dysbacteriosis Ecology Flora Food Science Functional foods & nutraceuticals Gastrointestinal Microbiome Gene expression Glucose Glucose metabolism Glucosidase Glycosidases High fat diet Hyperglycemia Hypoglycemic Agents - pharmacology In vivo methods and tests Insulin Insulin resistance Intestinal microflora Intestine Kinases Lipid metabolism Lipids Metabolism Mice Mice, Obese Nutrition Phosphatidylinositol 3-Kinases - metabolism Plant Physiology Selenium Signal transduction Streptozocin Tea α-Glucosidase |
| title | Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice |
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