mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading

Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its regulatory mechanism remains elusive. Here, we demonstrate that TOP mRNA translation positively correlates with its poly(A) tail l...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-10, Vol.41 (4), p.111548-111548, Article 111548
Hauptverfasser:	Ogami, Koichi, Oishi, Yuka, Sakamoto, Kentaro, Okumura, Mayu, Yamagishi, Ryota, Inoue, Takumi, Hibino, Masaya, Nogimori, Takuto, Yamaguchi, Natsumi, Furutachi, Kazuya, Hosoda, Nao, Inagaki, Hiroto, Hoshino, Shin-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid starvation deadenylation LARP1 mTOR poly(A) tail polyadenylation ribosome TOP mRNA translation
Online-Zugang:	Volltext
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