Effectiveness of influenza vaccination in reducing influenza-like illness and related antibiotic prescriptions in adults from a primary care-based case-control study
•Influenza vaccination reduced primary care presentations for ILI.•The pooled estimated reduction over 4 years was 24% (95%CI 11-34%).•Influenza vaccination also reduced antibiotic prescribing for ILI.•However, this was only observed in patients without comorbidities and aged 40-65yrs. Evidence on t...
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| Veröffentlicht in: | The Journal of infection 2022-12, Vol.85 (6), p.660-665 |
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| creator | He, Wen-Qiang Gianacas, Christopher Muscatello, David J Newall, Anthony T McIntyre, Peter Cheng, Allen C Liu, Bette |
| description | •Influenza vaccination reduced primary care presentations for ILI.•The pooled estimated reduction over 4 years was 24% (95%CI 11-34%).•Influenza vaccination also reduced antibiotic prescribing for ILI.•However, this was only observed in patients without comorbidities and aged 40-65yrs.
Evidence on the effectiveness of influenza vaccine in preventing antibiotic prescriptions for influenza-like illness (ILI) in adults is limited.
A primary care-based case-control study was conducted to estimate influenza vaccine effectiveness (VE) against influenza-like illness (ILI) and antibiotic prescribing for ILI in adults aged ≥40 years. Cases were patients diagnosed with ILI from 1st June to 30th September in each year, 2015-2018; a subset of those with ILI prescribed antibiotics was also defined. Controls were patients attending a practice who did not receive an ILI diagnosis. Generalised estimating equations were used to calculate adjusted VE overall, by age ( |
| doi_str_mv | 10.1016/j.jinf.2022.10.028 |
| format | Article |
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Evidence on the effectiveness of influenza vaccine in preventing antibiotic prescriptions for influenza-like illness (ILI) in adults is limited.
A primary care-based case-control study was conducted to estimate influenza vaccine effectiveness (VE) against influenza-like illness (ILI) and antibiotic prescribing for ILI in adults aged ≥40 years. Cases were patients diagnosed with ILI from 1st June to 30th September in each year, 2015-2018; a subset of those with ILI prescribed antibiotics was also defined. Controls were patients attending a practice who did not receive an ILI diagnosis. Generalised estimating equations were used to calculate adjusted VE overall, by age (<65 versus ≥65 years) and comorbidity status.
The number of ILI cases varied from 558 in 2018 to 2901 in 2017 and controls from 86618 in 2015 to 136763 in 2017. Over 4 years the pooled estimate of VE was 24% (95%CI, 11% to 34%) against ILI and 15% (95%CI, -3% to 29%) against antibiotic prescription for ILI. Influenza vaccine was effective in reducing ILI with an associated antibiotic prescriptions in patients aged <65 years (VE=23%, 95%CI, 3% to 38%) and if no comorbidities were recorded (VE=22%, 95%CI, 1% to 39%) but not in other subgroups.
Influenza vaccine reduced the likelihood of antibiotic prescriptions for ILI in low-risk adults (40-64 years and those without comorbidities).</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2022.10.028</identifier><identifier>PMID: 36288784</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Adults ; Anti-Bacterial Agents - therapeutic use ; Case-Control Studies ; Comorbidities ; Humans ; Influenza vaccination ; Influenza vaccine effectiveness ; Influenza Vaccines - therapeutic use ; Influenza, Human - drug therapy ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Influenza-like illness ; Prescriptions ; Primary Health Care ; Vaccination</subject><ispartof>The Journal of infection, 2022-12, Vol.85 (6), p.660-665</ispartof><rights>2022 The British Infection Association</rights><rights>Copyright © 2022 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-bbbe5398fb056af7fb8a7102795e1883afd3102e20b23e2b4e1e7e285a1da9b83</citedby><cites>FETCH-LOGICAL-c356t-bbbe5398fb056af7fb8a7102795e1883afd3102e20b23e2b4e1e7e285a1da9b83</cites><orcidid>0000-0003-0594-9007 ; 0000-0002-2391-4396 ; 0000-0002-7475-8485</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinf.2022.10.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36288784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Wen-Qiang</creatorcontrib><creatorcontrib>Gianacas, Christopher</creatorcontrib><creatorcontrib>Muscatello, David J</creatorcontrib><creatorcontrib>Newall, Anthony T</creatorcontrib><creatorcontrib>McIntyre, Peter</creatorcontrib><creatorcontrib>Cheng, Allen C</creatorcontrib><creatorcontrib>Liu, Bette</creatorcontrib><title>Effectiveness of influenza vaccination in reducing influenza-like illness and related antibiotic prescriptions in adults from a primary care-based case-control study</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>•Influenza vaccination reduced primary care presentations for ILI.•The pooled estimated reduction over 4 years was 24% (95%CI 11-34%).•Influenza vaccination also reduced antibiotic prescribing for ILI.•However, this was only observed in patients without comorbidities and aged 40-65yrs.
Evidence on the effectiveness of influenza vaccine in preventing antibiotic prescriptions for influenza-like illness (ILI) in adults is limited.
A primary care-based case-control study was conducted to estimate influenza vaccine effectiveness (VE) against influenza-like illness (ILI) and antibiotic prescribing for ILI in adults aged ≥40 years. Cases were patients diagnosed with ILI from 1st June to 30th September in each year, 2015-2018; a subset of those with ILI prescribed antibiotics was also defined. Controls were patients attending a practice who did not receive an ILI diagnosis. Generalised estimating equations were used to calculate adjusted VE overall, by age (<65 versus ≥65 years) and comorbidity status.
The number of ILI cases varied from 558 in 2018 to 2901 in 2017 and controls from 86618 in 2015 to 136763 in 2017. Over 4 years the pooled estimate of VE was 24% (95%CI, 11% to 34%) against ILI and 15% (95%CI, -3% to 29%) against antibiotic prescription for ILI. Influenza vaccine was effective in reducing ILI with an associated antibiotic prescriptions in patients aged <65 years (VE=23%, 95%CI, 3% to 38%) and if no comorbidities were recorded (VE=22%, 95%CI, 1% to 39%) but not in other subgroups.
Influenza vaccine reduced the likelihood of antibiotic prescriptions for ILI in low-risk adults (40-64 years and those without comorbidities).</description><subject>Adult</subject><subject>Adults</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Comorbidities</subject><subject>Humans</subject><subject>Influenza vaccination</subject><subject>Influenza vaccine effectiveness</subject><subject>Influenza Vaccines - therapeutic use</subject><subject>Influenza, Human - drug therapy</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - prevention & control</subject><subject>Influenza-like illness</subject><subject>Prescriptions</subject><subject>Primary Health Care</subject><subject>Vaccination</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcluFDEURS1ERJqEH2CBvGRTjYcaXBIbFIVBisQmWVsenpEbt93YrpbC_-Q_cdEN7NjYftfnXunpIvSaki0ldHy32-58dFtGGGvCljDxDG3owFnHpp49R5sG8a7vB36JXpayI4TMfB5foEs-MiEm0W_Q061zYKo_QoRScHK4RYYF4k-Fj8oYH1X1KTYVZ7BLm7_9I7rgvwP2Ifz2qmgbE1QF297Va5-qN_iQoZjsD2tMWXOUXUIt2OW0x6p9-73Kj9ioDJ1WpZlNOzuTYs0p4FIX-3iNLpwKBV6d7yv08PH2_uZzd_f105ebD3ed4cNYO601DHwWTpNhVG5yWqiJEjbNA1AhuHKWtxEY0YwD0z1QmICJQVGrZi34FXp7yj3k9GOBUuXeFwMhqAhpKZJNbB4Y68e5oeyEmpxKyeDkeRNJiVzrkTu51iPXelat1dNMb875i96D_Wv500cD3p8AaFsePWRZjIdowPrcapI2-f_l_wLZcqYa</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>He, Wen-Qiang</creator><creator>Gianacas, Christopher</creator><creator>Muscatello, David J</creator><creator>Newall, Anthony T</creator><creator>McIntyre, Peter</creator><creator>Cheng, Allen C</creator><creator>Liu, Bette</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0594-9007</orcidid><orcidid>https://orcid.org/0000-0002-2391-4396</orcidid><orcidid>https://orcid.org/0000-0002-7475-8485</orcidid></search><sort><creationdate>202212</creationdate><title>Effectiveness of influenza vaccination in reducing influenza-like illness and related antibiotic prescriptions in adults from a primary care-based case-control study</title><author>He, Wen-Qiang ; Gianacas, Christopher ; Muscatello, David J ; Newall, Anthony T ; McIntyre, Peter ; Cheng, Allen C ; Liu, Bette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-bbbe5398fb056af7fb8a7102795e1883afd3102e20b23e2b4e1e7e285a1da9b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Comorbidities</topic><topic>Humans</topic><topic>Influenza vaccination</topic><topic>Influenza vaccine effectiveness</topic><topic>Influenza Vaccines - therapeutic use</topic><topic>Influenza, Human - drug therapy</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - prevention & control</topic><topic>Influenza-like illness</topic><topic>Prescriptions</topic><topic>Primary Health Care</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Wen-Qiang</creatorcontrib><creatorcontrib>Gianacas, Christopher</creatorcontrib><creatorcontrib>Muscatello, David J</creatorcontrib><creatorcontrib>Newall, Anthony T</creatorcontrib><creatorcontrib>McIntyre, Peter</creatorcontrib><creatorcontrib>Cheng, Allen C</creatorcontrib><creatorcontrib>Liu, Bette</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Wen-Qiang</au><au>Gianacas, Christopher</au><au>Muscatello, David J</au><au>Newall, Anthony T</au><au>McIntyre, Peter</au><au>Cheng, Allen C</au><au>Liu, Bette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of influenza vaccination in reducing influenza-like illness and related antibiotic prescriptions in adults from a primary care-based case-control study</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>2022-12</date><risdate>2022</risdate><volume>85</volume><issue>6</issue><spage>660</spage><epage>665</epage><pages>660-665</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><abstract>•Influenza vaccination reduced primary care presentations for ILI.•The pooled estimated reduction over 4 years was 24% (95%CI 11-34%).•Influenza vaccination also reduced antibiotic prescribing for ILI.•However, this was only observed in patients without comorbidities and aged 40-65yrs.
Evidence on the effectiveness of influenza vaccine in preventing antibiotic prescriptions for influenza-like illness (ILI) in adults is limited.
A primary care-based case-control study was conducted to estimate influenza vaccine effectiveness (VE) against influenza-like illness (ILI) and antibiotic prescribing for ILI in adults aged ≥40 years. Cases were patients diagnosed with ILI from 1st June to 30th September in each year, 2015-2018; a subset of those with ILI prescribed antibiotics was also defined. Controls were patients attending a practice who did not receive an ILI diagnosis. Generalised estimating equations were used to calculate adjusted VE overall, by age (<65 versus ≥65 years) and comorbidity status.
The number of ILI cases varied from 558 in 2018 to 2901 in 2017 and controls from 86618 in 2015 to 136763 in 2017. Over 4 years the pooled estimate of VE was 24% (95%CI, 11% to 34%) against ILI and 15% (95%CI, -3% to 29%) against antibiotic prescription for ILI. Influenza vaccine was effective in reducing ILI with an associated antibiotic prescriptions in patients aged <65 years (VE=23%, 95%CI, 3% to 38%) and if no comorbidities were recorded (VE=22%, 95%CI, 1% to 39%) but not in other subgroups.
Influenza vaccine reduced the likelihood of antibiotic prescriptions for ILI in low-risk adults (40-64 years and those without comorbidities).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36288784</pmid><doi>10.1016/j.jinf.2022.10.028</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0594-9007</orcidid><orcidid>https://orcid.org/0000-0002-2391-4396</orcidid><orcidid>https://orcid.org/0000-0002-7475-8485</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adults Anti-Bacterial Agents - therapeutic use Case-Control Studies Comorbidities Humans Influenza vaccination Influenza vaccine effectiveness Influenza Vaccines - therapeutic use Influenza, Human - drug therapy Influenza, Human - epidemiology Influenza, Human - prevention & control Influenza-like illness Prescriptions Primary Health Care Vaccination |
| title | Effectiveness of influenza vaccination in reducing influenza-like illness and related antibiotic prescriptions in adults from a primary care-based case-control study |
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