Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database
Background Small intestine adenocarcinoma (SIA) is a scant disease that has no adequate clinical trials, so its prognostic factors are still unclear, especially in elderly patients. In this article, we aimed to explore the clinicopathology presentation, treatments, outcomes, and predictors of small...
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| Veröffentlicht in: | International journal of colorectal disease 2022-11, Vol.37 (11), p.2397-2407 |
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| creator | Liu, Qiu-Yan xie, Ling Yang, Xiao-Yun Yang, Lei Lei, Xiao-Lin |
| description | Background
Small intestine adenocarcinoma (SIA) is a scant disease that has no adequate clinical trials, so its prognostic factors are still unclear, especially in elderly patients. In this article, we aimed to explore the clinicopathology presentation, treatments, outcomes, and predictors of small intestine adenocarcinoma patients aged 65 years or older.
Methods
We retrieved clinicopathology data of small intestine adenocarcinoma patients diagnosed between 2004 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. We clarified patients into two groups: the surgery and the non-surgery group and conducted propensity score matching (PSM) to compare survival outcoming. We identified the prognostic indicators for cancer-specific survival (CSS) and overall survival (OS) by the Cox proportional hazards model.
Results
In total, 1018 eligible cases were enrolled, with a median survival of 16 months; the 3-year OS and CSS rates were 36% and 41.7%, and the 5-year OS and CSS rates were 26.5% and 33.3%. Multivariate analyses revealed that age, grade, tumor stage, surgery, and chemotherapy were independent prognostic factors for OS, while grade, tumor stage, surgery, radiation, and chemotherapy were independent factors for CSS. After PSM, only surgery and tumor stage (AJCC 6th) were independent prognostic factors for OS and CSS.
Conclusion
Surgery could bring benefit to survival for elderly SIA patients, and the early stage of the disease was another significant prognostic factor. |
| doi_str_mv | 10.1007/s00384-022-04266-9 |
| format | Article |
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Small intestine adenocarcinoma (SIA) is a scant disease that has no adequate clinical trials, so its prognostic factors are still unclear, especially in elderly patients. In this article, we aimed to explore the clinicopathology presentation, treatments, outcomes, and predictors of small intestine adenocarcinoma patients aged 65 years or older.
Methods
We retrieved clinicopathology data of small intestine adenocarcinoma patients diagnosed between 2004 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. We clarified patients into two groups: the surgery and the non-surgery group and conducted propensity score matching (PSM) to compare survival outcoming. We identified the prognostic indicators for cancer-specific survival (CSS) and overall survival (OS) by the Cox proportional hazards model.
Results
In total, 1018 eligible cases were enrolled, with a median survival of 16 months; the 3-year OS and CSS rates were 36% and 41.7%, and the 5-year OS and CSS rates were 26.5% and 33.3%. Multivariate analyses revealed that age, grade, tumor stage, surgery, and chemotherapy were independent prognostic factors for OS, while grade, tumor stage, surgery, radiation, and chemotherapy were independent factors for CSS. After PSM, only surgery and tumor stage (AJCC 6th) were independent prognostic factors for OS and CSS.
Conclusion
Surgery could bring benefit to survival for elderly SIA patients, and the early stage of the disease was another significant prognostic factor.</description><identifier>ISSN: 1432-1262</identifier><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-022-04266-9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenocarcinoma ; Analysis ; Cancer ; Chemotherapy ; Clinical trials ; Epidemiology ; Gastroenterology ; Hepatology ; Internal Medicine ; Medical prognosis ; Medicine ; Medicine & Public Health ; Patients ; Proctology ; Prognosis ; Small intestine ; Surgery ; Survival ; Tumors</subject><ispartof>International journal of colorectal disease, 2022-11, Vol.37 (11), p.2397-2407</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-1f889bb0d31bd99827ea6fc103629e024b08356f1178c45ad5a0bb884d8df6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-022-04266-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-022-04266-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Liu, Qiu-Yan</creatorcontrib><creatorcontrib>xie, Ling</creatorcontrib><creatorcontrib>Yang, Xiao-Yun</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Lei, Xiao-Lin</creatorcontrib><title>Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><description>Background
Small intestine adenocarcinoma (SIA) is a scant disease that has no adequate clinical trials, so its prognostic factors are still unclear, especially in elderly patients. In this article, we aimed to explore the clinicopathology presentation, treatments, outcomes, and predictors of small intestine adenocarcinoma patients aged 65 years or older.
Methods
We retrieved clinicopathology data of small intestine adenocarcinoma patients diagnosed between 2004 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. We clarified patients into two groups: the surgery and the non-surgery group and conducted propensity score matching (PSM) to compare survival outcoming. We identified the prognostic indicators for cancer-specific survival (CSS) and overall survival (OS) by the Cox proportional hazards model.
Results
In total, 1018 eligible cases were enrolled, with a median survival of 16 months; the 3-year OS and CSS rates were 36% and 41.7%, and the 5-year OS and CSS rates were 26.5% and 33.3%. Multivariate analyses revealed that age, grade, tumor stage, surgery, and chemotherapy were independent prognostic factors for OS, while grade, tumor stage, surgery, radiation, and chemotherapy were independent factors for CSS. After PSM, only surgery and tumor stage (AJCC 6th) were independent prognostic factors for OS and CSS.
Conclusion
Surgery could bring benefit to survival for elderly SIA patients, and the early stage of the disease was another significant prognostic factor.</description><subject>Adenocarcinoma</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Epidemiology</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Internal Medicine</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Patients</subject><subject>Proctology</subject><subject>Prognosis</subject><subject>Small intestine</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><issn>1432-1262</issn><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9ks1u1DAQxyMEEqXwApwsceGS4o_EcbhVqy1UqoQEvVsTf2RdOfZiO4d9KN6xDotUQAj5YHvm9x_PjKdp3hJ8RTAePmSMmehaTGmLO8p5Oz5rLkjHaEsop89_O79sXuX8gDEZ-NBdND923gWn4hHKIfo4OwUeqQMkUMUkl4tTGUHQ6JjiHOJ2R7b6YsooWmS8NsmfUF7Ae-RCMZUIBoE2ISpIyoW4AFqzC_MW4mhCdqXyKiaDFijqsHkggD9llz8iQLms-oQmyEajGNC3_f4r0lBgs7xuXljw2bz5tV829zf7-93n9u7Lp9vd9V2r2IBLS6wQ4zRhzcikx1HQwQC3imDG6Wgw7SYsWM8tIYNQXQ-6BzxNQnRaaMuBXTbvz2Frxt_XWpJcXFbGewgmrlnSgY597ehIK_ruL_QhrqmWs1GMsZHXJ5-oGbyRLthYaoO3oPJ6oD0fCBG8Ulf_oOrSZqlfFIx11f6HgJ4FKsWck7HymNwC6SQJlttcyPNcyDoX8udcyC0XdhblCofZpKeM_6N6BEbTvY0</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Liu, Qiu-Yan</creator><creator>xie, Ling</creator><creator>Yang, Xiao-Yun</creator><creator>Yang, Lei</creator><creator>Lei, Xiao-Lin</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20221101</creationdate><title>Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database</title><author>Liu, Qiu-Yan ; xie, Ling ; Yang, Xiao-Yun ; Yang, Lei ; Lei, Xiao-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-1f889bb0d31bd99827ea6fc103629e024b08356f1178c45ad5a0bb884d8df6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Epidemiology</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Internal Medicine</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Patients</topic><topic>Proctology</topic><topic>Prognosis</topic><topic>Small intestine</topic><topic>Surgery</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Qiu-Yan</creatorcontrib><creatorcontrib>xie, Ling</creatorcontrib><creatorcontrib>Yang, Xiao-Yun</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Lei, Xiao-Lin</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Qiu-Yan</au><au>xie, Ling</au><au>Yang, Xiao-Yun</au><au>Yang, Lei</au><au>Lei, Xiao-Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><date>2022-11-01</date><risdate>2022</risdate><volume>37</volume><issue>11</issue><spage>2397</spage><epage>2407</epage><pages>2397-2407</pages><issn>1432-1262</issn><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Background
Small intestine adenocarcinoma (SIA) is a scant disease that has no adequate clinical trials, so its prognostic factors are still unclear, especially in elderly patients. In this article, we aimed to explore the clinicopathology presentation, treatments, outcomes, and predictors of small intestine adenocarcinoma patients aged 65 years or older.
Methods
We retrieved clinicopathology data of small intestine adenocarcinoma patients diagnosed between 2004 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. We clarified patients into two groups: the surgery and the non-surgery group and conducted propensity score matching (PSM) to compare survival outcoming. We identified the prognostic indicators for cancer-specific survival (CSS) and overall survival (OS) by the Cox proportional hazards model.
Results
In total, 1018 eligible cases were enrolled, with a median survival of 16 months; the 3-year OS and CSS rates were 36% and 41.7%, and the 5-year OS and CSS rates were 26.5% and 33.3%. Multivariate analyses revealed that age, grade, tumor stage, surgery, and chemotherapy were independent prognostic factors for OS, while grade, tumor stage, surgery, radiation, and chemotherapy were independent factors for CSS. After PSM, only surgery and tumor stage (AJCC 6th) were independent prognostic factors for OS and CSS.
Conclusion
Surgery could bring benefit to survival for elderly SIA patients, and the early stage of the disease was another significant prognostic factor.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00384-022-04266-9</doi><tpages>11</tpages></addata></record> |
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| subjects | Adenocarcinoma Analysis Cancer Chemotherapy Clinical trials Epidemiology Gastroenterology Hepatology Internal Medicine Medical prognosis Medicine Medicine & Public Health Patients Proctology Prognosis Small intestine Surgery Survival Tumors |
| title | Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database |
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