Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021
BackgroundTo investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy.MethodsWe reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital...
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| Veröffentlicht in: | British journal of ophthalmology 2024-01, Vol.108 (1), p.58-64 |
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| creator | Yang, Hsin-Yu Chi, Sheng-Chu Ko, Yu-Chieh Chen, Mei-Ju Kuang, Tung-Mei Chang, Yu-Fan Liu, Catherine Jui-Ling |
| description | BackgroundTo investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy.MethodsWe reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital. We recorded the demographic and clinical characteristics of patients before, during and after surgery. Furthermore, we recorded the time interval between surgery and infection onset, clinical manifestations and visual outcomes of patients with BRI. The cumulative incidence of BRI was estimated using the Kaplan-Meier method. A Cox proportional hazards model was used to explore factors associated with BRI.ResultsIn total, 1663 eyes were postoperatively followed up for 94.57±65.23 months. The cumulative incidence of BRI was 1.86 per 1000 person-years during the 28-year follow-up period: 24 (1.44%) patients developed BRI and 6 (0.36%) patients additionally developed endophthalmitis. A multivariate analysis revealed a significant association of BRI with wound manipulation, high myopia and hyperlipidaemia. Patients younger than 60 years were more likely to receive wound manipulation than their elderly counterparts ( |
| doi_str_mv | 10.1136/bjo-2022-321429 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2729030930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2902866782</sourcerecordid><originalsourceid>FETCH-LOGICAL-b389t-a8958b80c21ebe99fa8d13e1ce9bc31a2ecea5fa78109eac73e8aa478eeae8693</originalsourceid><addsrcrecordid>eNp9kU1rGzEQhkVpaByn596CoJdC2EQj2Sspt9bkCwK5tLeAGMmzZM2u5Uq7Cf73VbDbQCEBgZD06J1hHsa-gDgDUPW5X8VKCikrJWEm7Qc2gVltypW2H9lECKErgBoO2VHOq3KUNehP7FDV0ihtzYQ9_OjIV4k6HGjJ23VDYWjjmmMzUOKb1PaYtnxI6CmMXXmM_faC97RsA3Y8PGIaeKKnlp4zb1LsOVir-BB56QqO2UGDXabP-33Kfl1d_lzcVHf317eL73eVV8YOFRo7N96IIIE8WdugWYIiCGR9UICSAuG8QW1AWMKgFRnEmTZESKa2asq-7XI3Kf4eKQ-ub3OgrsM1xTE7qaUVSlglCvr1P3QVx7Qu3bnCSFPX2sh3qZIF81lZhTrfUSHFnBM1bj8vB8K96HFFj3vR43Z6yo-Tfe7oywz_8X99FOB0B_h-9Vrzrbg_y-uXDA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729154154</pqid></control><display><type>article</type><title>Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021</title><source>PubMed Central</source><creator>Yang, Hsin-Yu ; Chi, Sheng-Chu ; Ko, Yu-Chieh ; Chen, Mei-Ju ; Kuang, Tung-Mei ; Chang, Yu-Fan ; Liu, Catherine Jui-Ling</creator><creatorcontrib>Yang, Hsin-Yu ; Chi, Sheng-Chu ; Ko, Yu-Chieh ; Chen, Mei-Ju ; Kuang, Tung-Mei ; Chang, Yu-Fan ; Liu, Catherine Jui-Ling</creatorcontrib><description>BackgroundTo investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy.MethodsWe reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital. We recorded the demographic and clinical characteristics of patients before, during and after surgery. Furthermore, we recorded the time interval between surgery and infection onset, clinical manifestations and visual outcomes of patients with BRI. The cumulative incidence of BRI was estimated using the Kaplan-Meier method. A Cox proportional hazards model was used to explore factors associated with BRI.ResultsIn total, 1663 eyes were postoperatively followed up for 94.57±65.23 months. The cumulative incidence of BRI was 1.86 per 1000 person-years during the 28-year follow-up period: 24 (1.44%) patients developed BRI and 6 (0.36%) patients additionally developed endophthalmitis. A multivariate analysis revealed a significant association of BRI with wound manipulation, high myopia and hyperlipidaemia. Patients younger than 60 years were more likely to receive wound manipulation than their elderly counterparts (<0.001). One year after BRI, the best corrected visual acuity of the eyes with blebitis did not change significantly, whereas that of the eyes with endophthalmitis worsened significantly.ConclusionRisk factors for BRI after trabeculectomy include wound manipulation, high myopia and hyperlipidaemia. Considering myopia is highly prevalent throughout the world and is a risk factor for glaucoma, the lifelong risk of BRI after trabeculectomy in eyes with high myopia warrants the attention of ophthalmologists.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo-2022-321429</identifier><identifier>PMID: 36283798</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Age ; Diabetes ; Eye surgery ; Glaucoma ; Hospitals ; Hypertension ; Infection ; Infections ; Medical personnel ; Myopia ; Patients ; Risk factors ; Software ; Statistical analysis ; Surgical outcomes ; Wound healing</subject><ispartof>British journal of ophthalmology, 2024-01, Vol.108 (1), p.58-64</ispartof><rights>Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2023 Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b389t-a8958b80c21ebe99fa8d13e1ce9bc31a2ecea5fa78109eac73e8aa478eeae8693</citedby><cites>FETCH-LOGICAL-b389t-a8958b80c21ebe99fa8d13e1ce9bc31a2ecea5fa78109eac73e8aa478eeae8693</cites><orcidid>0000-0003-3718-4117 ; 0000-0001-5168-8261</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36283798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Hsin-Yu</creatorcontrib><creatorcontrib>Chi, Sheng-Chu</creatorcontrib><creatorcontrib>Ko, Yu-Chieh</creatorcontrib><creatorcontrib>Chen, Mei-Ju</creatorcontrib><creatorcontrib>Kuang, Tung-Mei</creatorcontrib><creatorcontrib>Chang, Yu-Fan</creatorcontrib><creatorcontrib>Liu, Catherine Jui-Ling</creatorcontrib><title>Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><addtitle>Br J Ophthalmol</addtitle><description>BackgroundTo investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy.MethodsWe reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital. We recorded the demographic and clinical characteristics of patients before, during and after surgery. Furthermore, we recorded the time interval between surgery and infection onset, clinical manifestations and visual outcomes of patients with BRI. The cumulative incidence of BRI was estimated using the Kaplan-Meier method. A Cox proportional hazards model was used to explore factors associated with BRI.ResultsIn total, 1663 eyes were postoperatively followed up for 94.57±65.23 months. The cumulative incidence of BRI was 1.86 per 1000 person-years during the 28-year follow-up period: 24 (1.44%) patients developed BRI and 6 (0.36%) patients additionally developed endophthalmitis. A multivariate analysis revealed a significant association of BRI with wound manipulation, high myopia and hyperlipidaemia. Patients younger than 60 years were more likely to receive wound manipulation than their elderly counterparts (<0.001). One year after BRI, the best corrected visual acuity of the eyes with blebitis did not change significantly, whereas that of the eyes with endophthalmitis worsened significantly.ConclusionRisk factors for BRI after trabeculectomy include wound manipulation, high myopia and hyperlipidaemia. Considering myopia is highly prevalent throughout the world and is a risk factor for glaucoma, the lifelong risk of BRI after trabeculectomy in eyes with high myopia warrants the attention of ophthalmologists.</description><subject>Age</subject><subject>Diabetes</subject><subject>Eye surgery</subject><subject>Glaucoma</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Infection</subject><subject>Infections</subject><subject>Medical personnel</subject><subject>Myopia</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Surgical outcomes</subject><subject>Wound healing</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU1rGzEQhkVpaByn596CoJdC2EQj2Sspt9bkCwK5tLeAGMmzZM2u5Uq7Cf73VbDbQCEBgZD06J1hHsa-gDgDUPW5X8VKCikrJWEm7Qc2gVltypW2H9lECKErgBoO2VHOq3KUNehP7FDV0ihtzYQ9_OjIV4k6HGjJ23VDYWjjmmMzUOKb1PaYtnxI6CmMXXmM_faC97RsA3Y8PGIaeKKnlp4zb1LsOVir-BB56QqO2UGDXabP-33Kfl1d_lzcVHf317eL73eVV8YOFRo7N96IIIE8WdugWYIiCGR9UICSAuG8QW1AWMKgFRnEmTZESKa2asq-7XI3Kf4eKQ-ub3OgrsM1xTE7qaUVSlglCvr1P3QVx7Qu3bnCSFPX2sh3qZIF81lZhTrfUSHFnBM1bj8vB8K96HFFj3vR43Z6yo-Tfe7oywz_8X99FOB0B_h-9Vrzrbg_y-uXDA</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Yang, Hsin-Yu</creator><creator>Chi, Sheng-Chu</creator><creator>Ko, Yu-Chieh</creator><creator>Chen, Mei-Ju</creator><creator>Kuang, Tung-Mei</creator><creator>Chang, Yu-Fan</creator><creator>Liu, Catherine Jui-Ling</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3718-4117</orcidid><orcidid>https://orcid.org/0000-0001-5168-8261</orcidid></search><sort><creationdate>20240101</creationdate><title>Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021</title><author>Yang, Hsin-Yu ; Chi, Sheng-Chu ; Ko, Yu-Chieh ; Chen, Mei-Ju ; Kuang, Tung-Mei ; Chang, Yu-Fan ; Liu, Catherine Jui-Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b389t-a8958b80c21ebe99fa8d13e1ce9bc31a2ecea5fa78109eac73e8aa478eeae8693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Diabetes</topic><topic>Eye surgery</topic><topic>Glaucoma</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Infection</topic><topic>Infections</topic><topic>Medical personnel</topic><topic>Myopia</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Surgical outcomes</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Hsin-Yu</creatorcontrib><creatorcontrib>Chi, Sheng-Chu</creatorcontrib><creatorcontrib>Ko, Yu-Chieh</creatorcontrib><creatorcontrib>Chen, Mei-Ju</creatorcontrib><creatorcontrib>Kuang, Tung-Mei</creatorcontrib><creatorcontrib>Chang, Yu-Fan</creatorcontrib><creatorcontrib>Liu, Catherine Jui-Ling</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Hsin-Yu</au><au>Chi, Sheng-Chu</au><au>Ko, Yu-Chieh</au><au>Chen, Mei-Ju</au><au>Kuang, Tung-Mei</au><au>Chang, Yu-Fan</au><au>Liu, Catherine Jui-Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021</atitle><jtitle>British journal of ophthalmology</jtitle><stitle>Br J Ophthalmol</stitle><addtitle>Br J Ophthalmol</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>108</volume><issue>1</issue><spage>58</spage><epage>64</epage><pages>58-64</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract>BackgroundTo investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy.MethodsWe reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital. We recorded the demographic and clinical characteristics of patients before, during and after surgery. Furthermore, we recorded the time interval between surgery and infection onset, clinical manifestations and visual outcomes of patients with BRI. The cumulative incidence of BRI was estimated using the Kaplan-Meier method. A Cox proportional hazards model was used to explore factors associated with BRI.ResultsIn total, 1663 eyes were postoperatively followed up for 94.57±65.23 months. The cumulative incidence of BRI was 1.86 per 1000 person-years during the 28-year follow-up period: 24 (1.44%) patients developed BRI and 6 (0.36%) patients additionally developed endophthalmitis. A multivariate analysis revealed a significant association of BRI with wound manipulation, high myopia and hyperlipidaemia. Patients younger than 60 years were more likely to receive wound manipulation than their elderly counterparts (<0.001). One year after BRI, the best corrected visual acuity of the eyes with blebitis did not change significantly, whereas that of the eyes with endophthalmitis worsened significantly.ConclusionRisk factors for BRI after trabeculectomy include wound manipulation, high myopia and hyperlipidaemia. Considering myopia is highly prevalent throughout the world and is a risk factor for glaucoma, the lifelong risk of BRI after trabeculectomy in eyes with high myopia warrants the attention of ophthalmologists.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>36283798</pmid><doi>10.1136/bjo-2022-321429</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3718-4117</orcidid><orcidid>https://orcid.org/0000-0001-5168-8261</orcidid></addata></record> |
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| subjects | Age Diabetes Eye surgery Glaucoma Hospitals Hypertension Infection Infections Medical personnel Myopia Patients Risk factors Software Statistical analysis Surgical outcomes Wound healing |
| title | Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021 |
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