Duodenal Switch vs. Single-Anastomosis Duodenal Switch (SADI-S) for the Treatment of Grade IV Obesity: 5-Year Outcomes of a Multicenter Prospective Cohort Comparative Study

Purpose The aims were to compare the 5-year outcomes of duodenal switch (DS) and single-anastomosis duodenal switch (SADI-S) in terms of weight loss; remission of comorbidities; nutritional status short- and long-term complications; postoperative mortality; and need for revisional surgery. Materials...

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Veröffentlicht in:Obesity surgery 2022-12, Vol.32 (12), p.3839-3846
Hauptverfasser: Gebellí, Jordi Pujol, Lazzara, Claudio, de Gordejuela, Amador García Ruiz, Nora, Mario, Pereira, Ana Marta, Sánchez-Pernaute, Andrés, Osorio, Javier, Sobrino, Lucia, García, Antonio J. Torres
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container_end_page 3846
container_issue 12
container_start_page 3839
container_title Obesity surgery
container_volume 32
creator Gebellí, Jordi Pujol
Lazzara, Claudio
de Gordejuela, Amador García Ruiz
Nora, Mario
Pereira, Ana Marta
Sánchez-Pernaute, Andrés
Osorio, Javier
Sobrino, Lucia
García, Antonio J. Torres
description Purpose The aims were to compare the 5-year outcomes of duodenal switch (DS) and single-anastomosis duodenal switch (SADI-S) in terms of weight loss; remission of comorbidities; nutritional status short- and long-term complications; postoperative mortality; and need for revisional surgery. Materials and Methods Multicenter prospective observational study of all consecutive patients undergoing DS or SADI-S in three high-volume hospitals. Results A total of 87 patients were included in the study, 43 submitted to DS and 44 to SADI-S, with similar basal characteristics, nutritional parameters, and BMI (52.9 kg/m 2 DS vs. 52.5 kg/m 2 SADI-S). Operative time was 152 min (± 32.6) in DS vs. 116 min (± 21.9) in SADI-S ( p  = 0.043). Short-term complications were similar for DS and SADI-S, both overall (11.8% vs. 11.6%), and ranged as Clavien-Dindo > II (4.5% vs. 4.7%), with no mortality. At 5 years, DS and SADI-S results were as follows: BMI 30.6 vs. 33.3 kg/m 2 ( p  = 0.023); %EWL 80.5% vs. 68.6% ( p  = 0.006); and %TWL 42.1 vs. 36.0 ( p  = 0.006). Comorbidity remission rates for DS and SADI-S were as follows: for diabetes, 92.8% vs. 85.7% (n.s.); for hypertension, 95.2% vs. 85.1% (n.s.); for sleep apnea, 75% vs. 73.3% (n.s.); and for dyslipidemia, 76.4% vs. 73.3% (n.s.). DS showed lower levels of vitamin B 12 , iron, vitamin E, and zinc than SADI-S ( p  =  
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Torres</creator><creatorcontrib>Gebellí, Jordi Pujol ; Lazzara, Claudio ; de Gordejuela, Amador García Ruiz ; Nora, Mario ; Pereira, Ana Marta ; Sánchez-Pernaute, Andrés ; Osorio, Javier ; Sobrino, Lucia ; García, Antonio J. Torres</creatorcontrib><description>Purpose The aims were to compare the 5-year outcomes of duodenal switch (DS) and single-anastomosis duodenal switch (SADI-S) in terms of weight loss; remission of comorbidities; nutritional status short- and long-term complications; postoperative mortality; and need for revisional surgery. Materials and Methods Multicenter prospective observational study of all consecutive patients undergoing DS or SADI-S in three high-volume hospitals. Results A total of 87 patients were included in the study, 43 submitted to DS and 44 to SADI-S, with similar basal characteristics, nutritional parameters, and BMI (52.9 kg/m 2 DS vs. 52.5 kg/m 2 SADI-S). Operative time was 152 min (± 32.6) in DS vs. 116 min (± 21.9) in SADI-S ( p  = 0.043). Short-term complications were similar for DS and SADI-S, both overall (11.8% vs. 11.6%), and ranged as Clavien-Dindo &gt; II (4.5% vs. 4.7%), with no mortality. At 5 years, DS and SADI-S results were as follows: BMI 30.6 vs. 33.3 kg/m 2 ( p  = 0.023); %EWL 80.5% vs. 68.6% ( p  = 0.006); and %TWL 42.1 vs. 36.0 ( p  = 0.006). Comorbidity remission rates for DS and SADI-S were as follows: for diabetes, 92.8% vs. 85.7% (n.s.); for hypertension, 95.2% vs. 85.1% (n.s.); for sleep apnea, 75% vs. 73.3% (n.s.); and for dyslipidemia, 76.4% vs. 73.3% (n.s.). DS showed lower levels of vitamin B 12 , iron, vitamin E, and zinc than SADI-S ( p  =  &lt; 0.005). In the long term, there were 4 surgical reinterventions (due to 1 internal hernia in the DS group and 1 internal hernia and 2 biliary refluxes in the SADI-S group) with no cases of persistent diarrhea or malnutrition. Conclusion Both DS and SADI-S allowed good weight control and resolution of comorbidities. DS achieved a greater weight loss compared to SADI-S, at the expense of longer operative time and lower vitamin and mineral levels. Graphical abstract</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-022-06317-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cohort analysis ; Comorbidity ; Diabetes ; Diarrhea ; Gastrointestinal surgery ; Hernias ; Hospitals ; Malnutrition ; Medicine ; Medicine &amp; Public Health ; Metabolic disorders ; Mortality ; Nutritional status ; Obesity ; Observational studies ; Original Contributions ; Remission (Medicine) ; Sleep apnea ; Surgery ; Vitamin deficiency ; Weight control</subject><ispartof>Obesity surgery, 2022-12, Vol.32 (12), p.3839-3846</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-70fb2362dc271212e7f22f6a118a6073573e968147eba2af434300779fc80cda3</citedby><cites>FETCH-LOGICAL-c352t-70fb2362dc271212e7f22f6a118a6073573e968147eba2af434300779fc80cda3</cites><orcidid>0000-0002-4684-4538</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-022-06317-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-022-06317-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Gebellí, Jordi Pujol</creatorcontrib><creatorcontrib>Lazzara, Claudio</creatorcontrib><creatorcontrib>de Gordejuela, Amador García Ruiz</creatorcontrib><creatorcontrib>Nora, Mario</creatorcontrib><creatorcontrib>Pereira, Ana Marta</creatorcontrib><creatorcontrib>Sánchez-Pernaute, Andrés</creatorcontrib><creatorcontrib>Osorio, Javier</creatorcontrib><creatorcontrib>Sobrino, Lucia</creatorcontrib><creatorcontrib>García, Antonio J. Torres</creatorcontrib><title>Duodenal Switch vs. Single-Anastomosis Duodenal Switch (SADI-S) for the Treatment of Grade IV Obesity: 5-Year Outcomes of a Multicenter Prospective Cohort Comparative Study</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><description>Purpose The aims were to compare the 5-year outcomes of duodenal switch (DS) and single-anastomosis duodenal switch (SADI-S) in terms of weight loss; remission of comorbidities; nutritional status short- and long-term complications; postoperative mortality; and need for revisional surgery. Materials and Methods Multicenter prospective observational study of all consecutive patients undergoing DS or SADI-S in three high-volume hospitals. Results A total of 87 patients were included in the study, 43 submitted to DS and 44 to SADI-S, with similar basal characteristics, nutritional parameters, and BMI (52.9 kg/m 2 DS vs. 52.5 kg/m 2 SADI-S). Operative time was 152 min (± 32.6) in DS vs. 116 min (± 21.9) in SADI-S ( p  = 0.043). Short-term complications were similar for DS and SADI-S, both overall (11.8% vs. 11.6%), and ranged as Clavien-Dindo &gt; II (4.5% vs. 4.7%), with no mortality. At 5 years, DS and SADI-S results were as follows: BMI 30.6 vs. 33.3 kg/m 2 ( p  = 0.023); %EWL 80.5% vs. 68.6% ( p  = 0.006); and %TWL 42.1 vs. 36.0 ( p  = 0.006). Comorbidity remission rates for DS and SADI-S were as follows: for diabetes, 92.8% vs. 85.7% (n.s.); for hypertension, 95.2% vs. 85.1% (n.s.); for sleep apnea, 75% vs. 73.3% (n.s.); and for dyslipidemia, 76.4% vs. 73.3% (n.s.). DS showed lower levels of vitamin B 12 , iron, vitamin E, and zinc than SADI-S ( p  =  &lt; 0.005). In the long term, there were 4 surgical reinterventions (due to 1 internal hernia in the DS group and 1 internal hernia and 2 biliary refluxes in the SADI-S group) with no cases of persistent diarrhea or malnutrition. Conclusion Both DS and SADI-S allowed good weight control and resolution of comorbidities. DS achieved a greater weight loss compared to SADI-S, at the expense of longer operative time and lower vitamin and mineral levels. 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Torres</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duodenal Switch vs. Single-Anastomosis Duodenal Switch (SADI-S) for the Treatment of Grade IV Obesity: 5-Year Outcomes of a Multicenter Prospective Cohort Comparative Study</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>32</volume><issue>12</issue><spage>3839</spage><epage>3846</epage><pages>3839-3846</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Purpose The aims were to compare the 5-year outcomes of duodenal switch (DS) and single-anastomosis duodenal switch (SADI-S) in terms of weight loss; remission of comorbidities; nutritional status short- and long-term complications; postoperative mortality; and need for revisional surgery. Materials and Methods Multicenter prospective observational study of all consecutive patients undergoing DS or SADI-S in three high-volume hospitals. Results A total of 87 patients were included in the study, 43 submitted to DS and 44 to SADI-S, with similar basal characteristics, nutritional parameters, and BMI (52.9 kg/m 2 DS vs. 52.5 kg/m 2 SADI-S). Operative time was 152 min (± 32.6) in DS vs. 116 min (± 21.9) in SADI-S ( p  = 0.043). Short-term complications were similar for DS and SADI-S, both overall (11.8% vs. 11.6%), and ranged as Clavien-Dindo &gt; II (4.5% vs. 4.7%), with no mortality. At 5 years, DS and SADI-S results were as follows: BMI 30.6 vs. 33.3 kg/m 2 ( p  = 0.023); %EWL 80.5% vs. 68.6% ( p  = 0.006); and %TWL 42.1 vs. 36.0 ( p  = 0.006). Comorbidity remission rates for DS and SADI-S were as follows: for diabetes, 92.8% vs. 85.7% (n.s.); for hypertension, 95.2% vs. 85.1% (n.s.); for sleep apnea, 75% vs. 73.3% (n.s.); and for dyslipidemia, 76.4% vs. 73.3% (n.s.). DS showed lower levels of vitamin B 12 , iron, vitamin E, and zinc than SADI-S ( p  =  &lt; 0.005). In the long term, there were 4 surgical reinterventions (due to 1 internal hernia in the DS group and 1 internal hernia and 2 biliary refluxes in the SADI-S group) with no cases of persistent diarrhea or malnutrition. Conclusion Both DS and SADI-S allowed good weight control and resolution of comorbidities. DS achieved a greater weight loss compared to SADI-S, at the expense of longer operative time and lower vitamin and mineral levels. Graphical abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11695-022-06317-0</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4684-4538</orcidid></addata></record>
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subjects Cohort analysis
Comorbidity
Diabetes
Diarrhea
Gastrointestinal surgery
Hernias
Hospitals
Malnutrition
Medicine
Medicine & Public Health
Metabolic disorders
Mortality
Nutritional status
Obesity
Observational studies
Original Contributions
Remission (Medicine)
Sleep apnea
Surgery
Vitamin deficiency
Weight control
title Duodenal Switch vs. Single-Anastomosis Duodenal Switch (SADI-S) for the Treatment of Grade IV Obesity: 5-Year Outcomes of a Multicenter Prospective Cohort Comparative Study
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