Bone Marrow Adipokine Expression Was Associated With Decreased Erythroid Colony Growth After Trauma
Background Proinflammatory and immunomodulatory adipokines are linked to inflammation in critically ill patients but are poorly studied after injury. We hypothesized that trauma would induce systemic adipokine release and influence erythroid suppression. Methods Blood and bone marrow (BM) were colle...
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| Veröffentlicht in: | The American surgeon 2023-04, Vol.89 (4), p.558-565 |
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| container_title | The American surgeon |
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| creator | Kelly, Lauren S. Kannan, Kolenkode B. Munley, Jennifer A. Pons, Erick E. Parvataneni, Hari K. Hagen, Jennifer E. Efron, Philip A. Mohr, Alicia M. |
| description | Background
Proinflammatory and immunomodulatory adipokines are linked to inflammation in critically ill patients but are poorly studied after injury. We hypothesized that trauma would induce systemic adipokine release and influence erythroid suppression.
Methods
Blood and bone marrow (BM) were collected from trauma patients (ISS > 15, n = 90) and compared to patients undergoing elective hip replacement (n = 37). Plasma adipokine levels were measured, and BM was assayed for adipokine transcription and erythroid progenitor growth potential. Differences were detected using t-tests and correlations using simple linear regression.
Results
Trauma patients exhibited decreased adiponectin (1.8* vs 3.4 mg/mL) and increased leptin (7.8* vs 4.6 ng/mL) and resistin (3.1* vs 2.5 ng/mL), with sex- and age-specific differences. They also showed increased BM visfatin transcription. Adipokine transcription negatively correlated with erythroid progenitor growth.
Conclusion
Adipose tissue activity is linked to inflammatory responses after injury, with variability by age and sex. Bone marrow adipose tissue may influence erythroid recovery after trauma. |
| doi_str_mv | 10.1177/00031348221135772 |
| format | Article |
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Proinflammatory and immunomodulatory adipokines are linked to inflammation in critically ill patients but are poorly studied after injury. We hypothesized that trauma would induce systemic adipokine release and influence erythroid suppression.
Methods
Blood and bone marrow (BM) were collected from trauma patients (ISS > 15, n = 90) and compared to patients undergoing elective hip replacement (n = 37). Plasma adipokine levels were measured, and BM was assayed for adipokine transcription and erythroid progenitor growth potential. Differences were detected using t-tests and correlations using simple linear regression.
Results
Trauma patients exhibited decreased adiponectin (1.8* vs 3.4 mg/mL) and increased leptin (7.8* vs 4.6 ng/mL) and resistin (3.1* vs 2.5 ng/mL), with sex- and age-specific differences. They also showed increased BM visfatin transcription. Adipokine transcription negatively correlated with erythroid progenitor growth.
Conclusion
Adipose tissue activity is linked to inflammatory responses after injury, with variability by age and sex. Bone marrow adipose tissue may influence erythroid recovery after trauma.</description><identifier>ISSN: 0003-1348</identifier><identifier>EISSN: 1555-9823</identifier><identifier>DOI: 10.1177/00031348221135772</identifier><identifier>PMID: 36282510</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adipokines ; Adiponectin ; Adipose tissue ; Body mass index ; Bone marrow ; Bone Marrow - metabolism ; Diabetes ; Fractures ; Granulocytes ; Hemoglobin ; Humans ; Illnesses ; Immunomodulation ; Inflammation ; Informed consent ; Intensive care ; Length of stay ; Leptin ; Patients ; Plasma ; Polymerase chain reaction ; Sepsis ; Sex ; Software ; Transcription ; Trauma</subject><ispartof>The American surgeon, 2023-04, Vol.89 (4), p.558-565</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c320t-522542a745a9f16c3b6467dcfea6001147c266433650670cdfa636a52bb47d3c3</cites><orcidid>0000-0003-1732-1313 ; 0000-0001-5547-405X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/00031348221135772$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/00031348221135772$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36282510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, Lauren S.</creatorcontrib><creatorcontrib>Kannan, Kolenkode B.</creatorcontrib><creatorcontrib>Munley, Jennifer A.</creatorcontrib><creatorcontrib>Pons, Erick E.</creatorcontrib><creatorcontrib>Parvataneni, Hari K.</creatorcontrib><creatorcontrib>Hagen, Jennifer E.</creatorcontrib><creatorcontrib>Efron, Philip A.</creatorcontrib><creatorcontrib>Mohr, Alicia M.</creatorcontrib><title>Bone Marrow Adipokine Expression Was Associated With Decreased Erythroid Colony Growth After Trauma</title><title>The American surgeon</title><addtitle>Am Surg</addtitle><description>Background
Proinflammatory and immunomodulatory adipokines are linked to inflammation in critically ill patients but are poorly studied after injury. We hypothesized that trauma would induce systemic adipokine release and influence erythroid suppression.
Methods
Blood and bone marrow (BM) were collected from trauma patients (ISS > 15, n = 90) and compared to patients undergoing elective hip replacement (n = 37). Plasma adipokine levels were measured, and BM was assayed for adipokine transcription and erythroid progenitor growth potential. Differences were detected using t-tests and correlations using simple linear regression.
Results
Trauma patients exhibited decreased adiponectin (1.8* vs 3.4 mg/mL) and increased leptin (7.8* vs 4.6 ng/mL) and resistin (3.1* vs 2.5 ng/mL), with sex- and age-specific differences. They also showed increased BM visfatin transcription. Adipokine transcription negatively correlated with erythroid progenitor growth.
Conclusion
Adipose tissue activity is linked to inflammatory responses after injury, with variability by age and sex. Bone marrow adipose tissue may influence erythroid recovery after trauma.</description><subject>Adipokines</subject><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Body mass index</subject><subject>Bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Diabetes</subject><subject>Fractures</subject><subject>Granulocytes</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Informed consent</subject><subject>Intensive care</subject><subject>Length of stay</subject><subject>Leptin</subject><subject>Patients</subject><subject>Plasma</subject><subject>Polymerase chain reaction</subject><subject>Sepsis</subject><subject>Sex</subject><subject>Software</subject><subject>Transcription</subject><subject>Trauma</subject><issn>0003-1348</issn><issn>1555-9823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1PwjAYB_DGaATRD-DFNPHiZdj3jiMiognGC4bj0nWdDLd1tluUb28JqInGU_O0v-ffpg8A5xgNMZbyGiFEMWUxIRhTLiU5AH3MOY9GMaGHoL89j7agB068X4eSCY6PQY8KEhOOUR_oG1sb-Kics-9wnBWNfS3CxvSjccb7wtZwqTwce291oVqTwWXRruCt0c4oH8qp27QrZ4sMTmxp6w2chaAgxnlrHFw41VXqFBzlqvTmbL8OwPPddDG5j-ZPs4fJeB5pSlAbcUI4I0oyrkY5FpqmggmZ6dwogRDGTGoiBKNUcCQk0lmuBBWKkzRlMqOaDsDVLrdx9q0zvk2qwmtTlqo2tvMJkSRmgjFOAr38Rde2c3V4XUKREDGVQQaFd0o7670zedK4olJuk2CUbCeQ_JlA6LnYJ3dpZbLvjq8vD2C4A169mJ9r_0_8BHNii9E</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Kelly, Lauren S.</creator><creator>Kannan, Kolenkode B.</creator><creator>Munley, Jennifer A.</creator><creator>Pons, Erick E.</creator><creator>Parvataneni, Hari K.</creator><creator>Hagen, Jennifer E.</creator><creator>Efron, Philip A.</creator><creator>Mohr, Alicia M.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>4U-</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1732-1313</orcidid><orcidid>https://orcid.org/0000-0001-5547-405X</orcidid></search><sort><creationdate>202304</creationdate><title>Bone Marrow Adipokine Expression Was Associated With Decreased Erythroid Colony Growth After Trauma</title><author>Kelly, Lauren S. ; Kannan, Kolenkode B. ; Munley, Jennifer A. ; Pons, Erick E. ; Parvataneni, Hari K. ; Hagen, Jennifer E. ; Efron, Philip A. ; Mohr, Alicia M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-522542a745a9f16c3b6467dcfea6001147c266433650670cdfa636a52bb47d3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipokines</topic><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Body mass index</topic><topic>Bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Diabetes</topic><topic>Fractures</topic><topic>Granulocytes</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Informed consent</topic><topic>Intensive care</topic><topic>Length of stay</topic><topic>Leptin</topic><topic>Patients</topic><topic>Plasma</topic><topic>Polymerase chain reaction</topic><topic>Sepsis</topic><topic>Sex</topic><topic>Software</topic><topic>Transcription</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, Lauren S.</creatorcontrib><creatorcontrib>Kannan, Kolenkode B.</creatorcontrib><creatorcontrib>Munley, Jennifer A.</creatorcontrib><creatorcontrib>Pons, Erick E.</creatorcontrib><creatorcontrib>Parvataneni, Hari K.</creatorcontrib><creatorcontrib>Hagen, Jennifer E.</creatorcontrib><creatorcontrib>Efron, Philip A.</creatorcontrib><creatorcontrib>Mohr, Alicia M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American surgeon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelly, Lauren S.</au><au>Kannan, Kolenkode B.</au><au>Munley, Jennifer A.</au><au>Pons, Erick E.</au><au>Parvataneni, Hari K.</au><au>Hagen, Jennifer E.</au><au>Efron, Philip A.</au><au>Mohr, Alicia M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Marrow Adipokine Expression Was Associated With Decreased Erythroid Colony Growth After Trauma</atitle><jtitle>The American surgeon</jtitle><addtitle>Am Surg</addtitle><date>2023-04</date><risdate>2023</risdate><volume>89</volume><issue>4</issue><spage>558</spage><epage>565</epage><pages>558-565</pages><issn>0003-1348</issn><eissn>1555-9823</eissn><abstract>Background
Proinflammatory and immunomodulatory adipokines are linked to inflammation in critically ill patients but are poorly studied after injury. We hypothesized that trauma would induce systemic adipokine release and influence erythroid suppression.
Methods
Blood and bone marrow (BM) were collected from trauma patients (ISS > 15, n = 90) and compared to patients undergoing elective hip replacement (n = 37). Plasma adipokine levels were measured, and BM was assayed for adipokine transcription and erythroid progenitor growth potential. Differences were detected using t-tests and correlations using simple linear regression.
Results
Trauma patients exhibited decreased adiponectin (1.8* vs 3.4 mg/mL) and increased leptin (7.8* vs 4.6 ng/mL) and resistin (3.1* vs 2.5 ng/mL), with sex- and age-specific differences. They also showed increased BM visfatin transcription. Adipokine transcription negatively correlated with erythroid progenitor growth.
Conclusion
Adipose tissue activity is linked to inflammatory responses after injury, with variability by age and sex. Bone marrow adipose tissue may influence erythroid recovery after trauma.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>36282510</pmid><doi>10.1177/00031348221135772</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1732-1313</orcidid><orcidid>https://orcid.org/0000-0001-5547-405X</orcidid></addata></record> |
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| ispartof | The American surgeon, 2023-04, Vol.89 (4), p.558-565 |
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| subjects | Adipokines Adiponectin Adipose tissue Body mass index Bone marrow Bone Marrow - metabolism Diabetes Fractures Granulocytes Hemoglobin Humans Illnesses Immunomodulation Inflammation Informed consent Intensive care Length of stay Leptin Patients Plasma Polymerase chain reaction Sepsis Sex Software Transcription Trauma |
| title | Bone Marrow Adipokine Expression Was Associated With Decreased Erythroid Colony Growth After Trauma |
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