Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise

Abstract Objective This work aimed to investigate the effect of the SGLT2 inhibitor, dapagliflozin (DAPA), on cardiac function and the metabolic and hormonal response to moderate exercise in people with type 2 diabetes. Methods This was a double-blind, placebo-controlled crossover study with a 4-wee...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2023-04, Vol.108 (4), p.888-896
Hauptverfasser:	Herring, Roselle A, Parsons, Iain, Shojaee-Moradie, Fariba, Stevenage, Mary, Jackson, Nicola, Manders, Ralph, Umpleby, A Margot, Fielding, Barbara A, Davies, Melanie, Russell-Jones, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Benzhydryl Compounds Cardiac function Catecholamines Cross-Over Studies Dapagliflozin Development and progression Dextrose Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Echocardiography Fatty acids Glucagon Glucose Glucose - pharmacology Glucose metabolism Growth hormones Heart Humans Insulin Metabolism Oxygen consumption Placebos Sodium-Glucose Transporter 2 Inhibitors - pharmacology Sodium-Glucose Transporter 2 Inhibitors - therapeutic use Somatotropin Type 2 diabetes Ventricular Function, Left
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