Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting CD105 (endoglin), a component of the TGFβ rec...

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Veröffentlicht in:	Oncoimmunology 2022-12, Vol.11 (1), p.2131229
Hauptverfasser:	Lontos, Konstantinos, Wang, Yiyang, Colbert, Mason, Kumar, Alok, Joshi, Supriya, Philbin, Mary, Wang, Yupeng, Frisch, Andrew, Lohmueller, Jason, Rivadeneira, Dayana B., Delgoffe, Greg M.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia AML Animals B16 cd105 CD105 CAR-T cell Endoglin - metabolism Humans immunocompetent CAR-T Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Mice murine CAR-T cell Original Research Receptors, Chimeric Antigen T-Lymphocytes Transforming Growth Factor beta - metabolism
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