Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

BACKGROUNDWe explored the mechanism of maladaptive right ventricular (RV) remodeling in Fischer compared with Sprague-Dawley (SD) rats exposed to pressure overload. METHODSPulmonary hypertension was induced by injection of the VEGFR antagonist, SU5416, followed by a 3-week exposure to hypoxia (Sugen...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-12, Vol.79 (12), p.2774-2786
Hauptverfasser:	Zelt, Jason G.E., Cadete, Virgilio, Deng, Yupu, Godoy, Rafael, Cuillerier, Alexanne, Rowe, Katelynn, Abdul-Ghani, Mohammad, Megeney, Lynn, Burelle, Yan, Giulivi, Antonio, Stewart, Alexandre F.R., Provencher, Steeve, Breuils-Bonnet, Sandra, Bonnet, Sébastien, deKemp, Robert, Beanlands, Rob, Mielniczuk, Lisa M., Stewart, Duncan J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!