Disease course and treatment outcomes of Crohn's disease patients with early or late surgery – A Danish nationwide cohort study from 1997 to 2015
Studies on early surgery among Crohn's disease patients are few and focus on ileocolonic resections. The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery. In a Danish nationwide co...
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| Veröffentlicht in: | Digestive and liver disease 2023-07, Vol.55 (7), p.872-879 |
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| creator | Sarikaya, M.Z. Zhao, M. Lo, B. Bendtsen, F. Burisch, J. |
| description | Studies on early surgery among Crohn's disease patients are few and focus on ileocolonic resections.
The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery.
In a Danish nationwide cohort of Crohn's disease patients from 1997 to 2015 we included 493 patients (group 1) resected within 29 days, 472 patients (group 2) resected between 30 and 180 days, and 1,518 patients (group 3) resected after 180 days of diagnosis. Re-operation, hospitalisations and medications were analysed.
The cumulative risk of re-operation was lower among patients from group 1 (five-year risk: 16.5% vs. group 2: 18.2% and group 3: 21.2%, p = 0.004). Fewer patients from group 2 and 3 required hospitalisations (269 (56.5%) and 803 (52.8%) vs. group 1: 329 (66.8%) p |
| doi_str_mv | 10.1016/j.dld.2022.09.016 |
| format | Article |
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The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery.
In a Danish nationwide cohort of Crohn's disease patients from 1997 to 2015 we included 493 patients (group 1) resected within 29 days, 472 patients (group 2) resected between 30 and 180 days, and 1,518 patients (group 3) resected after 180 days of diagnosis. Re-operation, hospitalisations and medications were analysed.
The cumulative risk of re-operation was lower among patients from group 1 (five-year risk: 16.5% vs. group 2: 18.2% and group 3: 21.2%, p = 0.004). Fewer patients from group 2 and 3 required hospitalisations (269 (56.5%) and 803 (52.8%) vs. group 1: 329 (66.8%) p<0.001). Patients from group 3 had a higher cumulative use of immunomodulators in the first three years after initial surgery (one-year risk: 24.6% vs. group 1: 19.4% and group 2: 17.0%, p<0.001).
Crohn's disease patients resected within 29 days of diagnosis had a lower cumulative risk of re-operation and a lower cumulative exposure to immunomodulators in the initial years after surgery.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2022.09.016</identifier><identifier>PMID: 36266208</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Cohort Studies ; Crohn ; Crohn Disease - drug therapy ; Crohn Disease - surgery ; Denmark ; Disease Progression ; Humans ; IBD ; Immunologic Factors - therapeutic use ; Retrospective Studies ; Surgery ; Treatment Outcome</subject><ispartof>Digestive and liver disease, 2023-07, Vol.55 (7), p.872-879</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-b2d3509772bd67cb93e5cd1fd1ec1044a6662a17a3ee87bc58c1e2af2cc4c483</citedby><cites>FETCH-LOGICAL-c396t-b2d3509772bd67cb93e5cd1fd1ec1044a6662a17a3ee87bc58c1e2af2cc4c483</cites><orcidid>0000-0001-9707-9875</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2022.09.016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36266208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarikaya, M.Z.</creatorcontrib><creatorcontrib>Zhao, M.</creatorcontrib><creatorcontrib>Lo, B.</creatorcontrib><creatorcontrib>Bendtsen, F.</creatorcontrib><creatorcontrib>Burisch, J.</creatorcontrib><title>Disease course and treatment outcomes of Crohn's disease patients with early or late surgery – A Danish nationwide cohort study from 1997 to 2015</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Studies on early surgery among Crohn's disease patients are few and focus on ileocolonic resections.
The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery.
In a Danish nationwide cohort of Crohn's disease patients from 1997 to 2015 we included 493 patients (group 1) resected within 29 days, 472 patients (group 2) resected between 30 and 180 days, and 1,518 patients (group 3) resected after 180 days of diagnosis. Re-operation, hospitalisations and medications were analysed.
The cumulative risk of re-operation was lower among patients from group 1 (five-year risk: 16.5% vs. group 2: 18.2% and group 3: 21.2%, p = 0.004). Fewer patients from group 2 and 3 required hospitalisations (269 (56.5%) and 803 (52.8%) vs. group 1: 329 (66.8%) p<0.001). Patients from group 3 had a higher cumulative use of immunomodulators in the first three years after initial surgery (one-year risk: 24.6% vs. group 1: 19.4% and group 2: 17.0%, p<0.001).
Crohn's disease patients resected within 29 days of diagnosis had a lower cumulative risk of re-operation and a lower cumulative exposure to immunomodulators in the initial years after surgery.</description><subject>Cohort Studies</subject><subject>Crohn</subject><subject>Crohn Disease - drug therapy</subject><subject>Crohn Disease - surgery</subject><subject>Denmark</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>IBD</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhSMEYn7gAGxQ7WCTYDuJf8Rq1AMD0khsZm85doV2K4kb22HUO-4wN-QkuNUNS1ZVKn3vlapeVb2hpKGE8g-7xk2uYYSxhqimTJ5Vl1QKWbc9Z89L3ytSS97Li-oqpR0hjPKevKwuWs44Z0ReVk-3PqFJCDassRSzOMgRTZ5xyRDWbMOMCcIImxi2y7sE7izYm-wLk-DR5y2gidMBQoTJZIS0xu8YD_D71xPcwK1ZfNrCUgRhefTuuGwbYoaUV3eAMYYZqFICcgBGaP-qejGaKeHrc72uHj5_eth8qe-_3X3d3NzXtlU81wNzbU-UEGxwXNhBtdhbR0dH0VLSdYaXGw0VpkWUYrC9tBSZGZm1ne1ke129P9nuY_ixYsp69sniNJkFw5o0E0zwrlOyKyg9oTaGlCKOeh_9bOJBU6KPUeidLlHoYxSaKF0mRfP2bL8OM7p_ir-_L8DHE4Dlxp8eo062fNSi8xFt1i74_9j_AQzNm4o</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Sarikaya, M.Z.</creator><creator>Zhao, M.</creator><creator>Lo, B.</creator><creator>Bendtsen, F.</creator><creator>Burisch, J.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9707-9875</orcidid></search><sort><creationdate>202307</creationdate><title>Disease course and treatment outcomes of Crohn's disease patients with early or late surgery – A Danish nationwide cohort study from 1997 to 2015</title><author>Sarikaya, M.Z. ; Zhao, M. ; Lo, B. ; Bendtsen, F. ; Burisch, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-b2d3509772bd67cb93e5cd1fd1ec1044a6662a17a3ee87bc58c1e2af2cc4c483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cohort Studies</topic><topic>Crohn</topic><topic>Crohn Disease - drug therapy</topic><topic>Crohn Disease - surgery</topic><topic>Denmark</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>IBD</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarikaya, M.Z.</creatorcontrib><creatorcontrib>Zhao, M.</creatorcontrib><creatorcontrib>Lo, B.</creatorcontrib><creatorcontrib>Bendtsen, F.</creatorcontrib><creatorcontrib>Burisch, J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarikaya, M.Z.</au><au>Zhao, M.</au><au>Lo, B.</au><au>Bendtsen, F.</au><au>Burisch, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disease course and treatment outcomes of Crohn's disease patients with early or late surgery – A Danish nationwide cohort study from 1997 to 2015</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2023-07</date><risdate>2023</risdate><volume>55</volume><issue>7</issue><spage>872</spage><epage>879</epage><pages>872-879</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Studies on early surgery among Crohn's disease patients are few and focus on ileocolonic resections.
The aim of this nationwide cohort study was to investigate the disease course in all Crohn's disease patients who underwent early and late major abdominal surgery.
In a Danish nationwide cohort of Crohn's disease patients from 1997 to 2015 we included 493 patients (group 1) resected within 29 days, 472 patients (group 2) resected between 30 and 180 days, and 1,518 patients (group 3) resected after 180 days of diagnosis. Re-operation, hospitalisations and medications were analysed.
The cumulative risk of re-operation was lower among patients from group 1 (five-year risk: 16.5% vs. group 2: 18.2% and group 3: 21.2%, p = 0.004). Fewer patients from group 2 and 3 required hospitalisations (269 (56.5%) and 803 (52.8%) vs. group 1: 329 (66.8%) p<0.001). Patients from group 3 had a higher cumulative use of immunomodulators in the first three years after initial surgery (one-year risk: 24.6% vs. group 1: 19.4% and group 2: 17.0%, p<0.001).
Crohn's disease patients resected within 29 days of diagnosis had a lower cumulative risk of re-operation and a lower cumulative exposure to immunomodulators in the initial years after surgery.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>36266208</pmid><doi>10.1016/j.dld.2022.09.016</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9707-9875</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cohort Studies Crohn Crohn Disease - drug therapy Crohn Disease - surgery Denmark Disease Progression Humans IBD Immunologic Factors - therapeutic use Retrospective Studies Surgery Treatment Outcome |
| title | Disease course and treatment outcomes of Crohn's disease patients with early or late surgery – A Danish nationwide cohort study from 1997 to 2015 |
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