Transcriptional regulation of autophagy by RNA polymerase II
Macroautophagy/autophagy is a catabolic recycling pathway and is tightly regulated by upstream signals. Autophagy genes are quickly upregulated upon stimuli such as nutrition limitation in response to the external environment. However, how the transcriptional activation of autophagy genes occurs is...
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| Veröffentlicht in: | Autophagy 2023-06, Vol.19 (6), p.1867-1868 |
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| container_end_page | 1868 |
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| container_issue | 6 |
| container_start_page | 1867 |
| container_title | Autophagy |
| container_volume | 19 |
| creator | Lei, Yuqing Huang, Ting Jiang, Gaoyue Zhang, Yabin Liu, Shiyan Li, Huihui Lu, Kefeng |
| description | Macroautophagy/autophagy is a catabolic recycling pathway and is tightly regulated by upstream signals. Autophagy genes are quickly upregulated upon stimuli such as nutrition limitation in response to the external environment. However, how the transcriptional activation of autophagy genes occurs is not well understood. We recently found that in yeast, the RNA polymerase II subunit Rpb9 specifically and efficiently upregulates the transcription of the autophagy gene ATG1 with the mediation of Gcn4. Such regulation was shown to be essential for autophagic activities induced by starvation. Furthermore, the function of Rpb9 in autophagy and the activation of ATG1 transcription is conserved in mammalian cells. In conclusion, Rpb9 specifically and positively regulates ATG1 transcription as a key regulator of autophagy. |
| doi_str_mv | 10.1080/15548627.2022.2138141 |
| format | Article |
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| subjects | Animals ATG1 gene Autophagic Punctum autophagy Autophagy - genetics Gcn4 Gene Expression Regulation Mammals - metabolism RNA Polymerase II - genetics RNA Polymerase II - metabolism Rpb9 Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism starvation transcription yeast |
| title | Transcriptional regulation of autophagy by RNA polymerase II |
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