Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by clinical heterogeneity and flare unpredictability. It was still unclear for the association between SLE flare and immunophenotypes. Flow cytometric analysis defined the B and T subsets of the low disease activity state (LDA...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2022-12, Vol.245, p.109166-109166, Article 109166 |
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| container_title | Clinical immunology (Orlando, Fla.) |
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| creator | Zheng, Jian Zhu, Li Ju, Bomiao Zhang, Jing Luo, Jing Wang, Yanhua Lv, XiaoHong Pu, Dan He, Lan Wang, Jing |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by clinical heterogeneity and flare unpredictability. It was still unclear for the association between SLE flare and immunophenotypes. Flow cytometric analysis defined the B and T subsets of the low disease activity state (LDAS) patients and healthy controls. Principal components analysis (PCA) and cluster analysis (CA) distinguished the immunophenotypes. Compared with the 66 healthy controls, the 93 LDAS patients had higher proportions of plasma cells, double negative B cells, naïve B cells and CD8+T cells, and lower proportions of unswitched memory B cells and CD4+T cells. PCA showed the abnormalities of T and B cell axes. CA divided the patients into 3 groups. The memory B cells group had the lower flare risk compared with the non-memory B cells group (including naïve B cells group and T cells group). The immunophenotypes were associated with SLE flare in the LDAS patients. |
| doi_str_mv | 10.1016/j.clim.2022.109166 |
| format | Article |
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It was still unclear for the association between SLE flare and immunophenotypes. Flow cytometric analysis defined the B and T subsets of the low disease activity state (LDAS) patients and healthy controls. Principal components analysis (PCA) and cluster analysis (CA) distinguished the immunophenotypes. Compared with the 66 healthy controls, the 93 LDAS patients had higher proportions of plasma cells, double negative B cells, naïve B cells and CD8+T cells, and lower proportions of unswitched memory B cells and CD4+T cells. PCA showed the abnormalities of T and B cell axes. CA divided the patients into 3 groups. The memory B cells group had the lower flare risk compared with the non-memory B cells group (including naïve B cells group and T cells group). The immunophenotypes were associated with SLE flare in the LDAS patients.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2022.109166</identifier><identifier>PMID: 36270468</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>B-Lymphocytes ; Flare ; Flow Cytometry ; Humans ; Immunophenotypes ; Immunophenotyping ; Low disease activity state ; Lupus Erythematosus, Systemic ; Plasma Cells ; Systemic lupus erythematosus</subject><ispartof>Clinical immunology (Orlando, Fla.), 2022-12, Vol.245, p.109166-109166, Article 109166</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ec4116d0b7ae3beeab22cad29668c723dc7484c5a8f2404e51efa7d30fc79e73</citedby><cites>FETCH-LOGICAL-c356t-ec4116d0b7ae3beeab22cad29668c723dc7484c5a8f2404e51efa7d30fc79e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clim.2022.109166$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36270468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Jian</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Ju, Bomiao</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Luo, Jing</creatorcontrib><creatorcontrib>Wang, Yanhua</creatorcontrib><creatorcontrib>Lv, XiaoHong</creatorcontrib><creatorcontrib>Pu, Dan</creatorcontrib><creatorcontrib>He, Lan</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><title>Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by clinical heterogeneity and flare unpredictability. It was still unclear for the association between SLE flare and immunophenotypes. Flow cytometric analysis defined the B and T subsets of the low disease activity state (LDAS) patients and healthy controls. Principal components analysis (PCA) and cluster analysis (CA) distinguished the immunophenotypes. Compared with the 66 healthy controls, the 93 LDAS patients had higher proportions of plasma cells, double negative B cells, naïve B cells and CD8+T cells, and lower proportions of unswitched memory B cells and CD4+T cells. PCA showed the abnormalities of T and B cell axes. CA divided the patients into 3 groups. The memory B cells group had the lower flare risk compared with the non-memory B cells group (including naïve B cells group and T cells group). The immunophenotypes were associated with SLE flare in the LDAS patients.</description><subject>B-Lymphocytes</subject><subject>Flare</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunophenotypes</subject><subject>Immunophenotyping</subject><subject>Low disease activity state</subject><subject>Lupus Erythematosus, Systemic</subject><subject>Plasma Cells</subject><subject>Systemic lupus erythematosus</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P4zAQxa0VKwrsfoE9rHzk0mI7id1KXBDin1SJPXC3XHuiukrirMcpypVPjksKR04zb_Tek-ZHyB_OFpxxebVb2Ma3C8GEyIcVl_IHOeOV4HPFiurkuEvJ5YycI-4YY5UQ8pTMCikUK-XyjLz9g-j7LUTTUN-2Qxey6EIae0BqEIP1JoGjrz5tadoCrRsTgfruQ-CICVpvaTP0A1KIY762JgXMqjfJQ5dwyjbhlTqPYBCoscnvfRopplz-i_ysTYPw-zgvyMv93cvt43z9_PB0e7Oe26KSaQ625Fw6tlEGig2A2QhhjRMrKZdWicJZVS5LW5llLUpWQsWhNsoVrLZqBaq4IJdTbR_D_wEw6dajhaYxHYQBtVBCyVIU7GAVk9XGgBih1n30rYmj5kwf0OudPqDXB_R6Qp9Df4_9w6YF9xX5ZJ0N15MB8pN7D1GjzYAsOB_BJu2C_67_HYDrmWo</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Zheng, Jian</creator><creator>Zhu, Li</creator><creator>Ju, Bomiao</creator><creator>Zhang, Jing</creator><creator>Luo, Jing</creator><creator>Wang, Yanhua</creator><creator>Lv, XiaoHong</creator><creator>Pu, Dan</creator><creator>He, Lan</creator><creator>Wang, Jing</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202212</creationdate><title>Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state</title><author>Zheng, Jian ; Zhu, Li ; Ju, Bomiao ; Zhang, Jing ; Luo, Jing ; Wang, Yanhua ; Lv, XiaoHong ; Pu, Dan ; He, Lan ; Wang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ec4116d0b7ae3beeab22cad29668c723dc7484c5a8f2404e51efa7d30fc79e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>B-Lymphocytes</topic><topic>Flare</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunophenotypes</topic><topic>Immunophenotyping</topic><topic>Low disease activity state</topic><topic>Lupus Erythematosus, Systemic</topic><topic>Plasma Cells</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Jian</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Ju, Bomiao</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Luo, Jing</creatorcontrib><creatorcontrib>Wang, Yanhua</creatorcontrib><creatorcontrib>Lv, XiaoHong</creatorcontrib><creatorcontrib>Pu, Dan</creatorcontrib><creatorcontrib>He, Lan</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Jian</au><au>Zhu, Li</au><au>Ju, Bomiao</au><au>Zhang, Jing</au><au>Luo, Jing</au><au>Wang, Yanhua</au><au>Lv, XiaoHong</au><au>Pu, Dan</au><au>He, Lan</au><au>Wang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>245</volume><spage>109166</spage><epage>109166</epage><pages>109166-109166</pages><artnum>109166</artnum><issn>1521-6616</issn><eissn>1521-7035</eissn><abstract>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by clinical heterogeneity and flare unpredictability. It was still unclear for the association between SLE flare and immunophenotypes. Flow cytometric analysis defined the B and T subsets of the low disease activity state (LDAS) patients and healthy controls. Principal components analysis (PCA) and cluster analysis (CA) distinguished the immunophenotypes. Compared with the 66 healthy controls, the 93 LDAS patients had higher proportions of plasma cells, double negative B cells, naïve B cells and CD8+T cells, and lower proportions of unswitched memory B cells and CD4+T cells. PCA showed the abnormalities of T and B cell axes. CA divided the patients into 3 groups. The memory B cells group had the lower flare risk compared with the non-memory B cells group (including naïve B cells group and T cells group). The immunophenotypes were associated with SLE flare in the LDAS patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36270468</pmid><doi>10.1016/j.clim.2022.109166</doi><tpages>1</tpages></addata></record> |
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| subjects | B-Lymphocytes Flare Flow Cytometry Humans Immunophenotypes Immunophenotyping Low disease activity state Lupus Erythematosus, Systemic Plasma Cells Systemic lupus erythematosus |
| title | Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state |
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