Creative biological lignin conversion routes toward lignin valorization
Lignin, the largest renewable aromatic resource, is a promising alternative feedstock for the sustainable production of various chemicals, fuels, and materials. Despite this potential, lignin is characterized by heterogeneous and macromolecular structures that must be addressed. In this review, we p...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2022-12, Vol.40 (12), p.1550-1566 |
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| description | Lignin, the largest renewable aromatic resource, is a promising alternative feedstock for the sustainable production of various chemicals, fuels, and materials. Despite this potential, lignin is characterized by heterogeneous and macromolecular structures that must be addressed. In this review, we present biological lignin conversion routes (BLCRs) that offer opportunities for overcoming these challenges, making lignin valorization feasible. Funneling heterogeneous aromatics via a ‘biological funnel’ offers a high-specificity bioconversion route for aromatic platform chemicals. The inherent aromaticity of lignin drives atom-economic functionalization routes toward aromatic natural product generation. By harnessing the ligninolytic capacities of specific microbial systems, powerful aromatic ring-opening routes can be developed to generate various value-added products. Thus, BLCRs hold the promise to make lignin valorization feasible and enable a lignocellulose-based bioeconomy.
Biological lignin conversion routes (BLCRs) overcome the heterogeneous structures of lignin by harnessing the inherent capacity of ligninolytic microbes, opening the way to value-added products.Lignin depolymerization provides bioavailable aromatic derivatives suitable for downstream bioconversion.Atom-economic conversion routes are backbones in taping into the inherent aromaticity value of lignin to promote the microbial synthesis of valuable products.The scientific and technical evolution of synthetic biology enable the construction of microbial cell factories to improve lignin bioconversion.Lignin bioconversion would enable the economic viability of biorefineries and contribute to a sustainable lignocellulose-based bioeconomy. |
| doi_str_mv | 10.1016/j.tibtech.2022.09.014 |
| format | Article |
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Biological lignin conversion routes (BLCRs) overcome the heterogeneous structures of lignin by harnessing the inherent capacity of ligninolytic microbes, opening the way to value-added products.Lignin depolymerization provides bioavailable aromatic derivatives suitable for downstream bioconversion.Atom-economic conversion routes are backbones in taping into the inherent aromaticity value of lignin to promote the microbial synthesis of valuable products.The scientific and technical evolution of synthetic biology enable the construction of microbial cell factories to improve lignin bioconversion.Lignin bioconversion would enable the economic viability of biorefineries and contribute to a sustainable lignocellulose-based bioeconomy.</description><identifier>ISSN: 0167-7799</identifier><identifier>EISSN: 1879-3096</identifier><identifier>DOI: 10.1016/j.tibtech.2022.09.014</identifier><identifier>PMID: 36270902</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acids ; Aromatic compounds ; aromatic natural product ; Aromaticity ; Atom economy ; Bacteria ; Bioavailability ; Biochemistry ; Bioconversion ; biological funnel ; Carbohydrates ; Carbon ; carbon neutrality ; Catalysis ; Chemicals ; Deconstruction ; E coli ; Enzymes ; Lignin ; Lignin - chemistry ; lignin valorization ; Lignocellulose ; Macromolecules ; Metabolism ; Microorganisms ; Molecular structure ; Molecular weight ; Natural products ; Ring opening ; sustainable biorefinery ; Sustainable production ; synthetic biology</subject><ispartof>Trends in biotechnology (Regular ed.), 2022-12, Vol.40 (12), p.1550-1566</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>2022. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-efffc9a24cad9b70cfbc3cadae4a7ab55de62c098ad75b365b689faad215e3333</citedby><cites>FETCH-LOGICAL-c323t-efffc9a24cad9b70cfbc3cadae4a7ab55de62c098ad75b365b689faad215e3333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2734602337?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36270902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zhi-Hua</creatorcontrib><creatorcontrib>Li, Bing-Zhi</creatorcontrib><creatorcontrib>Yuan, Joshua S.</creatorcontrib><creatorcontrib>Yuan, Ying-Jin</creatorcontrib><title>Creative biological lignin conversion routes toward lignin valorization</title><title>Trends in biotechnology (Regular ed.)</title><addtitle>Trends Biotechnol</addtitle><description>Lignin, the largest renewable aromatic resource, is a promising alternative feedstock for the sustainable production of various chemicals, fuels, and materials. Despite this potential, lignin is characterized by heterogeneous and macromolecular structures that must be addressed. In this review, we present biological lignin conversion routes (BLCRs) that offer opportunities for overcoming these challenges, making lignin valorization feasible. Funneling heterogeneous aromatics via a ‘biological funnel’ offers a high-specificity bioconversion route for aromatic platform chemicals. The inherent aromaticity of lignin drives atom-economic functionalization routes toward aromatic natural product generation. By harnessing the ligninolytic capacities of specific microbial systems, powerful aromatic ring-opening routes can be developed to generate various value-added products. Thus, BLCRs hold the promise to make lignin valorization feasible and enable a lignocellulose-based bioeconomy.
Biological lignin conversion routes (BLCRs) overcome the heterogeneous structures of lignin by harnessing the inherent capacity of ligninolytic microbes, opening the way to value-added products.Lignin depolymerization provides bioavailable aromatic derivatives suitable for downstream bioconversion.Atom-economic conversion routes are backbones in taping into the inherent aromaticity value of lignin to promote the microbial synthesis of valuable products.The scientific and technical evolution of synthetic biology enable the construction of microbial cell factories to improve lignin bioconversion.Lignin bioconversion would enable the economic viability of biorefineries and contribute to a sustainable lignocellulose-based bioeconomy.</description><subject>Acids</subject><subject>Aromatic compounds</subject><subject>aromatic natural product</subject><subject>Aromaticity</subject><subject>Atom economy</subject><subject>Bacteria</subject><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Bioconversion</subject><subject>biological funnel</subject><subject>Carbohydrates</subject><subject>Carbon</subject><subject>carbon neutrality</subject><subject>Catalysis</subject><subject>Chemicals</subject><subject>Deconstruction</subject><subject>E coli</subject><subject>Enzymes</subject><subject>Lignin</subject><subject>Lignin - chemistry</subject><subject>lignin valorization</subject><subject>Lignocellulose</subject><subject>Macromolecules</subject><subject>Metabolism</subject><subject>Microorganisms</subject><subject>Molecular structure</subject><subject>Molecular weight</subject><subject>Natural products</subject><subject>Ring opening</subject><subject>sustainable biorefinery</subject><subject>Sustainable production</subject><subject>synthetic 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Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in biotechnology (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhi-Hua</au><au>Li, Bing-Zhi</au><au>Yuan, Joshua S.</au><au>Yuan, Ying-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Creative biological lignin conversion routes toward lignin valorization</atitle><jtitle>Trends in biotechnology (Regular ed.)</jtitle><addtitle>Trends Biotechnol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>40</volume><issue>12</issue><spage>1550</spage><epage>1566</epage><pages>1550-1566</pages><issn>0167-7799</issn><eissn>1879-3096</eissn><abstract>Lignin, the largest renewable aromatic resource, is a promising alternative feedstock for the sustainable production of various chemicals, fuels, and materials. Despite this potential, lignin is characterized by heterogeneous and macromolecular structures that must be addressed. In this review, we present biological lignin conversion routes (BLCRs) that offer opportunities for overcoming these challenges, making lignin valorization feasible. Funneling heterogeneous aromatics via a ‘biological funnel’ offers a high-specificity bioconversion route for aromatic platform chemicals. The inherent aromaticity of lignin drives atom-economic functionalization routes toward aromatic natural product generation. By harnessing the ligninolytic capacities of specific microbial systems, powerful aromatic ring-opening routes can be developed to generate various value-added products. Thus, BLCRs hold the promise to make lignin valorization feasible and enable a lignocellulose-based bioeconomy.
Biological lignin conversion routes (BLCRs) overcome the heterogeneous structures of lignin by harnessing the inherent capacity of ligninolytic microbes, opening the way to value-added products.Lignin depolymerization provides bioavailable aromatic derivatives suitable for downstream bioconversion.Atom-economic conversion routes are backbones in taping into the inherent aromaticity value of lignin to promote the microbial synthesis of valuable products.The scientific and technical evolution of synthetic biology enable the construction of microbial cell factories to improve lignin bioconversion.Lignin bioconversion would enable the economic viability of biorefineries and contribute to a sustainable lignocellulose-based bioeconomy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36270902</pmid><doi>10.1016/j.tibtech.2022.09.014</doi><tpages>17</tpages></addata></record> |
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| subjects | Acids Aromatic compounds aromatic natural product Aromaticity Atom economy Bacteria Bioavailability Biochemistry Bioconversion biological funnel Carbohydrates Carbon carbon neutrality Catalysis Chemicals Deconstruction E coli Enzymes Lignin Lignin - chemistry lignin valorization Lignocellulose Macromolecules Metabolism Microorganisms Molecular structure Molecular weight Natural products Ring opening sustainable biorefinery Sustainable production synthetic biology |
| title | Creative biological lignin conversion routes toward lignin valorization |
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