Impact of medications on salivary flow rate in patients with xerostomia: a retrospective study by the Xeromeds Consortium
Objectives This study evaluates the impact of systemic medications and polypharmacy on unstimulated (UWS) and chewing-stimulated whole saliva (SWS) flow rates in patients with xerostomia. Material and methods This cross-sectional multicenter study is based on data of patients referred to five oral m...
Gespeichert in:
| Veröffentlicht in: | Clinical oral investigations 2023-01, Vol.27 (1), p.235-248 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 248 |
|---|---|
| container_issue | 1 |
| container_start_page | 235 |
| container_title | Clinical oral investigations |
| container_volume | 27 |
| creator | Fortuna, Giulio Whitmire, Sarah Sullivan, Kathleen Alajbeg, Ivan Andabak-Rogulj, Ana Pedersen, Anne Marie Lynge Vissink, Arjan di Fede, Olga Aria, Massimo Jager, Derk Jan Noll, Jenene Jensen, Siri Beier Wolff, Andy Brennan, Michael T. |
| description | Objectives
This study evaluates the impact of systemic medications and polypharmacy on unstimulated (UWS) and chewing-stimulated whole saliva (SWS) flow rates in patients with xerostomia.
Material and methods
This cross-sectional multicenter study is based on data of patients referred to five oral medicine outpatient practices in Europe and USA from January 2000 and April 2014. Relevant demographic, social, medical history and current medications were collected.
Results
The study included 1144 patients, 972 (85%) females, with a mean (SD) age of 59 (14.1) years. In unmatched patients, the UWS flow rate was lower in patients taking a medication (vs. not taking a medication) from the following drug categories: opioid analgesics, anticonvulsants, antidepressants, antihypertensives, benzodiazepines, corticosteroids, diuretics, disease-modifying antirheumatic drugs (DMARDs) and hormones. There was a greater negative effect on SWS flow rate in patients taking (vs. not taking) anticonvulsants, antidepressants, benzodiazepines, corticosteroids, and DMARDs. In matched patients, both UWS (0.22 vs. 0.19 ml/min;
p
= 0.03) and SWS (0.97 vs. 0.85 ml/min;
p
= .017) flow rates were higher in patients on non-opioid analgesics (vs. not taking). The UWS flow rate was lower in patients taking antidepressants (vs. not taking) (0.16 vs. 0.22 ml/min
p
= .002) and higher (and within normal range) in patients taking sex hormones (vs. not taking) (0.25 vs. 0.16 ml/min;
p
= .005). On the other hand, SWS was lower in patients taking corticosteroid (vs. not taking) (0.76 vs. 1.07 ml/min;
p
= .002), and in patients taking DMARDs (vs. not taking) (0.71 vs. 0.98 ml/min;
p
= .021).
Finally, differences in medians of both UWS and SWS were statistically significant in patients taking 1 or more than 1 opioid analgesic (vs. not taking,
p
≤ .0001 and
p
= .031, respectively), 1 or more than 1 anticonvulsants (vs. not taking,
p
= .008 and
p
= .007), 1 or more than 1 antidepressants (vs. not taking,
p
|
| doi_str_mv | 10.1007/s00784-022-04717-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2727640815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2727640815</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-eddf351f62bf197783d1c2119667378241cf983178f3832ae62e459508ad35673</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi0Eohd4ARbIEptuAh7bsZ3u0FFvUiU2ILGzfBKbukri1HZaztsz9JSLWLDx2Jpv_vHMT8gbYO-BMf2h4GFkwzhvmNSgG3hGDkEK1Qit4flf9wNyVMotYyCVFi_JgVBcdVKZQ7K7mhbXV5oCnfwQe1djmgtNMy1ujPcu72gY0wPNrnoaZ7og4Oda6EOsN_S7z6nUNEV3Sh3NvuJz8X2N956Wug47ut3ReuPpVwRRv9ANqqdc4zq9Ii-CG4t__RSPyZfzs8-by-b608XV5uN100voauOHIYgWguLbAJ3WRgzQc4BO4SjacAl96IwAbYIwgjuvuJdt1zLjBtEic0xO9rpLTnerL9VOsfR-HN3s01os11wryQy0iL77B71Na57xd0gpg206LZDie6rHaUv2wS45TrgpC8z-NMbujbFojH00xgIWvX2SXre4iN8lv5xAQOyBgqn5m89_ev9H9ge1ZJkd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2768983973</pqid></control><display><type>article</type><title>Impact of medications on salivary flow rate in patients with xerostomia: a retrospective study by the Xeromeds Consortium</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Fortuna, Giulio ; Whitmire, Sarah ; Sullivan, Kathleen ; Alajbeg, Ivan ; Andabak-Rogulj, Ana ; Pedersen, Anne Marie Lynge ; Vissink, Arjan ; di Fede, Olga ; Aria, Massimo ; Jager, Derk Jan ; Noll, Jenene ; Jensen, Siri Beier ; Wolff, Andy ; Brennan, Michael T.</creator><creatorcontrib>Fortuna, Giulio ; Whitmire, Sarah ; Sullivan, Kathleen ; Alajbeg, Ivan ; Andabak-Rogulj, Ana ; Pedersen, Anne Marie Lynge ; Vissink, Arjan ; di Fede, Olga ; Aria, Massimo ; Jager, Derk Jan ; Noll, Jenene ; Jensen, Siri Beier ; Wolff, Andy ; Brennan, Michael T.</creatorcontrib><description>Objectives
This study evaluates the impact of systemic medications and polypharmacy on unstimulated (UWS) and chewing-stimulated whole saliva (SWS) flow rates in patients with xerostomia.
Material and methods
This cross-sectional multicenter study is based on data of patients referred to five oral medicine outpatient practices in Europe and USA from January 2000 and April 2014. Relevant demographic, social, medical history and current medications were collected.
Results
The study included 1144 patients, 972 (85%) females, with a mean (SD) age of 59 (14.1) years. In unmatched patients, the UWS flow rate was lower in patients taking a medication (vs. not taking a medication) from the following drug categories: opioid analgesics, anticonvulsants, antidepressants, antihypertensives, benzodiazepines, corticosteroids, diuretics, disease-modifying antirheumatic drugs (DMARDs) and hormones. There was a greater negative effect on SWS flow rate in patients taking (vs. not taking) anticonvulsants, antidepressants, benzodiazepines, corticosteroids, and DMARDs. In matched patients, both UWS (0.22 vs. 0.19 ml/min;
p
= 0.03) and SWS (0.97 vs. 0.85 ml/min;
p
= .017) flow rates were higher in patients on non-opioid analgesics (vs. not taking). The UWS flow rate was lower in patients taking antidepressants (vs. not taking) (0.16 vs. 0.22 ml/min
p
= .002) and higher (and within normal range) in patients taking sex hormones (vs. not taking) (0.25 vs. 0.16 ml/min;
p
= .005). On the other hand, SWS was lower in patients taking corticosteroid (vs. not taking) (0.76 vs. 1.07 ml/min;
p
= .002), and in patients taking DMARDs (vs. not taking) (0.71 vs. 0.98 ml/min;
p
= .021).
Finally, differences in medians of both UWS and SWS were statistically significant in patients taking 1 or more than 1 opioid analgesic (vs. not taking,
p
≤ .0001 and
p
= .031, respectively), 1 or more than 1 anticonvulsants (vs. not taking,
p
= .008 and
p
= .007), 1 or more than 1 antidepressants (vs. not taking,
p
< .0001 for both), 1 or more than 1 DMARDs (vs. not taking,
p
= .042, and
p
= .003).
Conclusions
A greater negative impact on UWS and SWS flow rates was seen in patients taking more than one medication from the same drug class. Intake of antidepressants, corticosteroids and DMARDs is associated with lower whole saliva flow rates.
Clinical relevance
Salivary flow rate can be modified by some specific medications, mostly by polypharmacy.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-022-04717-1</identifier><identifier>PMID: 36269468</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analgesics ; Anticonvulsants ; Antidepressants ; Antidepressive Agents - therapeutic use ; Antihypertensives ; Antirheumatic Agents ; Benzodiazepines ; Corticosteroids ; Cross-Sectional Studies ; Dentistry ; Diuretics ; Female ; Humans ; Male ; Medicine ; Middle Aged ; Narcotics ; Opioids ; Original Article ; Patients ; Polypharmacy ; Retrospective Studies ; Saliva ; Sex hormones ; Statistical analysis ; Steroids ; Xerostomia</subject><ispartof>Clinical oral investigations, 2023-01, Vol.27 (1), p.235-248</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-eddf351f62bf197783d1c2119667378241cf983178f3832ae62e459508ad35673</citedby><cites>FETCH-LOGICAL-c419t-eddf351f62bf197783d1c2119667378241cf983178f3832ae62e459508ad35673</cites><orcidid>0000-0003-0638-4335</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-022-04717-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-022-04717-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36269468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fortuna, Giulio</creatorcontrib><creatorcontrib>Whitmire, Sarah</creatorcontrib><creatorcontrib>Sullivan, Kathleen</creatorcontrib><creatorcontrib>Alajbeg, Ivan</creatorcontrib><creatorcontrib>Andabak-Rogulj, Ana</creatorcontrib><creatorcontrib>Pedersen, Anne Marie Lynge</creatorcontrib><creatorcontrib>Vissink, Arjan</creatorcontrib><creatorcontrib>di Fede, Olga</creatorcontrib><creatorcontrib>Aria, Massimo</creatorcontrib><creatorcontrib>Jager, Derk Jan</creatorcontrib><creatorcontrib>Noll, Jenene</creatorcontrib><creatorcontrib>Jensen, Siri Beier</creatorcontrib><creatorcontrib>Wolff, Andy</creatorcontrib><creatorcontrib>Brennan, Michael T.</creatorcontrib><title>Impact of medications on salivary flow rate in patients with xerostomia: a retrospective study by the Xeromeds Consortium</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
This study evaluates the impact of systemic medications and polypharmacy on unstimulated (UWS) and chewing-stimulated whole saliva (SWS) flow rates in patients with xerostomia.
Material and methods
This cross-sectional multicenter study is based on data of patients referred to five oral medicine outpatient practices in Europe and USA from January 2000 and April 2014. Relevant demographic, social, medical history and current medications were collected.
Results
The study included 1144 patients, 972 (85%) females, with a mean (SD) age of 59 (14.1) years. In unmatched patients, the UWS flow rate was lower in patients taking a medication (vs. not taking a medication) from the following drug categories: opioid analgesics, anticonvulsants, antidepressants, antihypertensives, benzodiazepines, corticosteroids, diuretics, disease-modifying antirheumatic drugs (DMARDs) and hormones. There was a greater negative effect on SWS flow rate in patients taking (vs. not taking) anticonvulsants, antidepressants, benzodiazepines, corticosteroids, and DMARDs. In matched patients, both UWS (0.22 vs. 0.19 ml/min;
p
= 0.03) and SWS (0.97 vs. 0.85 ml/min;
p
= .017) flow rates were higher in patients on non-opioid analgesics (vs. not taking). The UWS flow rate was lower in patients taking antidepressants (vs. not taking) (0.16 vs. 0.22 ml/min
p
= .002) and higher (and within normal range) in patients taking sex hormones (vs. not taking) (0.25 vs. 0.16 ml/min;
p
= .005). On the other hand, SWS was lower in patients taking corticosteroid (vs. not taking) (0.76 vs. 1.07 ml/min;
p
= .002), and in patients taking DMARDs (vs. not taking) (0.71 vs. 0.98 ml/min;
p
= .021).
Finally, differences in medians of both UWS and SWS were statistically significant in patients taking 1 or more than 1 opioid analgesic (vs. not taking,
p
≤ .0001 and
p
= .031, respectively), 1 or more than 1 anticonvulsants (vs. not taking,
p
= .008 and
p
= .007), 1 or more than 1 antidepressants (vs. not taking,
p
< .0001 for both), 1 or more than 1 DMARDs (vs. not taking,
p
= .042, and
p
= .003).
Conclusions
A greater negative impact on UWS and SWS flow rates was seen in patients taking more than one medication from the same drug class. Intake of antidepressants, corticosteroids and DMARDs is associated with lower whole saliva flow rates.
Clinical relevance
Salivary flow rate can be modified by some specific medications, mostly by polypharmacy.</description><subject>Analgesics</subject><subject>Anticonvulsants</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Antirheumatic Agents</subject><subject>Benzodiazepines</subject><subject>Corticosteroids</subject><subject>Cross-Sectional Studies</subject><subject>Dentistry</subject><subject>Diuretics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Narcotics</subject><subject>Opioids</subject><subject>Original Article</subject><subject>Patients</subject><subject>Polypharmacy</subject><subject>Retrospective Studies</subject><subject>Saliva</subject><subject>Sex hormones</subject><subject>Statistical analysis</subject><subject>Steroids</subject><subject>Xerostomia</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctu1TAQhi0Eohd4ARbIEptuAh7bsZ3u0FFvUiU2ILGzfBKbukri1HZaztsz9JSLWLDx2Jpv_vHMT8gbYO-BMf2h4GFkwzhvmNSgG3hGDkEK1Qit4flf9wNyVMotYyCVFi_JgVBcdVKZQ7K7mhbXV5oCnfwQe1djmgtNMy1ujPcu72gY0wPNrnoaZ7og4Oda6EOsN_S7z6nUNEV3Sh3NvuJz8X2N956Wug47ut3ReuPpVwRRv9ANqqdc4zq9Ii-CG4t__RSPyZfzs8-by-b608XV5uN100voauOHIYgWguLbAJ3WRgzQc4BO4SjacAl96IwAbYIwgjuvuJdt1zLjBtEic0xO9rpLTnerL9VOsfR-HN3s01os11wryQy0iL77B71Na57xd0gpg206LZDie6rHaUv2wS45TrgpC8z-NMbujbFojH00xgIWvX2SXre4iN8lv5xAQOyBgqn5m89_ev9H9ge1ZJkd</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Fortuna, Giulio</creator><creator>Whitmire, Sarah</creator><creator>Sullivan, Kathleen</creator><creator>Alajbeg, Ivan</creator><creator>Andabak-Rogulj, Ana</creator><creator>Pedersen, Anne Marie Lynge</creator><creator>Vissink, Arjan</creator><creator>di Fede, Olga</creator><creator>Aria, Massimo</creator><creator>Jager, Derk Jan</creator><creator>Noll, Jenene</creator><creator>Jensen, Siri Beier</creator><creator>Wolff, Andy</creator><creator>Brennan, Michael T.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0638-4335</orcidid></search><sort><creationdate>20230101</creationdate><title>Impact of medications on salivary flow rate in patients with xerostomia: a retrospective study by the Xeromeds Consortium</title><author>Fortuna, Giulio ; Whitmire, Sarah ; Sullivan, Kathleen ; Alajbeg, Ivan ; Andabak-Rogulj, Ana ; Pedersen, Anne Marie Lynge ; Vissink, Arjan ; di Fede, Olga ; Aria, Massimo ; Jager, Derk Jan ; Noll, Jenene ; Jensen, Siri Beier ; Wolff, Andy ; Brennan, Michael T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-eddf351f62bf197783d1c2119667378241cf983178f3832ae62e459508ad35673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analgesics</topic><topic>Anticonvulsants</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Antihypertensives</topic><topic>Antirheumatic Agents</topic><topic>Benzodiazepines</topic><topic>Corticosteroids</topic><topic>Cross-Sectional Studies</topic><topic>Dentistry</topic><topic>Diuretics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Narcotics</topic><topic>Opioids</topic><topic>Original Article</topic><topic>Patients</topic><topic>Polypharmacy</topic><topic>Retrospective Studies</topic><topic>Saliva</topic><topic>Sex hormones</topic><topic>Statistical analysis</topic><topic>Steroids</topic><topic>Xerostomia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fortuna, Giulio</creatorcontrib><creatorcontrib>Whitmire, Sarah</creatorcontrib><creatorcontrib>Sullivan, Kathleen</creatorcontrib><creatorcontrib>Alajbeg, Ivan</creatorcontrib><creatorcontrib>Andabak-Rogulj, Ana</creatorcontrib><creatorcontrib>Pedersen, Anne Marie Lynge</creatorcontrib><creatorcontrib>Vissink, Arjan</creatorcontrib><creatorcontrib>di Fede, Olga</creatorcontrib><creatorcontrib>Aria, Massimo</creatorcontrib><creatorcontrib>Jager, Derk Jan</creatorcontrib><creatorcontrib>Noll, Jenene</creatorcontrib><creatorcontrib>Jensen, Siri Beier</creatorcontrib><creatorcontrib>Wolff, Andy</creatorcontrib><creatorcontrib>Brennan, Michael T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fortuna, Giulio</au><au>Whitmire, Sarah</au><au>Sullivan, Kathleen</au><au>Alajbeg, Ivan</au><au>Andabak-Rogulj, Ana</au><au>Pedersen, Anne Marie Lynge</au><au>Vissink, Arjan</au><au>di Fede, Olga</au><au>Aria, Massimo</au><au>Jager, Derk Jan</au><au>Noll, Jenene</au><au>Jensen, Siri Beier</au><au>Wolff, Andy</au><au>Brennan, Michael T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of medications on salivary flow rate in patients with xerostomia: a retrospective study by the Xeromeds Consortium</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>27</volume><issue>1</issue><spage>235</spage><epage>248</epage><pages>235-248</pages><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
This study evaluates the impact of systemic medications and polypharmacy on unstimulated (UWS) and chewing-stimulated whole saliva (SWS) flow rates in patients with xerostomia.
Material and methods
This cross-sectional multicenter study is based on data of patients referred to five oral medicine outpatient practices in Europe and USA from January 2000 and April 2014. Relevant demographic, social, medical history and current medications were collected.
Results
The study included 1144 patients, 972 (85%) females, with a mean (SD) age of 59 (14.1) years. In unmatched patients, the UWS flow rate was lower in patients taking a medication (vs. not taking a medication) from the following drug categories: opioid analgesics, anticonvulsants, antidepressants, antihypertensives, benzodiazepines, corticosteroids, diuretics, disease-modifying antirheumatic drugs (DMARDs) and hormones. There was a greater negative effect on SWS flow rate in patients taking (vs. not taking) anticonvulsants, antidepressants, benzodiazepines, corticosteroids, and DMARDs. In matched patients, both UWS (0.22 vs. 0.19 ml/min;
p
= 0.03) and SWS (0.97 vs. 0.85 ml/min;
p
= .017) flow rates were higher in patients on non-opioid analgesics (vs. not taking). The UWS flow rate was lower in patients taking antidepressants (vs. not taking) (0.16 vs. 0.22 ml/min
p
= .002) and higher (and within normal range) in patients taking sex hormones (vs. not taking) (0.25 vs. 0.16 ml/min;
p
= .005). On the other hand, SWS was lower in patients taking corticosteroid (vs. not taking) (0.76 vs. 1.07 ml/min;
p
= .002), and in patients taking DMARDs (vs. not taking) (0.71 vs. 0.98 ml/min;
p
= .021).
Finally, differences in medians of both UWS and SWS were statistically significant in patients taking 1 or more than 1 opioid analgesic (vs. not taking,
p
≤ .0001 and
p
= .031, respectively), 1 or more than 1 anticonvulsants (vs. not taking,
p
= .008 and
p
= .007), 1 or more than 1 antidepressants (vs. not taking,
p
< .0001 for both), 1 or more than 1 DMARDs (vs. not taking,
p
= .042, and
p
= .003).
Conclusions
A greater negative impact on UWS and SWS flow rates was seen in patients taking more than one medication from the same drug class. Intake of antidepressants, corticosteroids and DMARDs is associated with lower whole saliva flow rates.
Clinical relevance
Salivary flow rate can be modified by some specific medications, mostly by polypharmacy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36269468</pmid><doi>10.1007/s00784-022-04717-1</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0638-4335</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-3771 |
| ispartof | Clinical oral investigations, 2023-01, Vol.27 (1), p.235-248 |
| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2727640815 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Analgesics Anticonvulsants Antidepressants Antidepressive Agents - therapeutic use Antihypertensives Antirheumatic Agents Benzodiazepines Corticosteroids Cross-Sectional Studies Dentistry Diuretics Female Humans Male Medicine Middle Aged Narcotics Opioids Original Article Patients Polypharmacy Retrospective Studies Saliva Sex hormones Statistical analysis Steroids Xerostomia |
| title | Impact of medications on salivary flow rate in patients with xerostomia: a retrospective study by the Xeromeds Consortium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T06%3A45%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20medications%20on%20salivary%20flow%20rate%20in%20patients%20with%20xerostomia:%20a%20retrospective%20study%20by%20the%20Xeromeds%20Consortium&rft.jtitle=Clinical%20oral%20investigations&rft.au=Fortuna,%20Giulio&rft.date=2023-01-01&rft.volume=27&rft.issue=1&rft.spage=235&rft.epage=248&rft.pages=235-248&rft.issn=1436-3771&rft.eissn=1436-3771&rft_id=info:doi/10.1007/s00784-022-04717-1&rft_dat=%3Cproquest_cross%3E2727640815%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2768983973&rft_id=info:pmid/36269468&rfr_iscdi=true |