Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-mediated tumor rejection, but the underlying mechanisms are incompletely understood. Here, we identified CD40-induced genes in cDC1s, including Cd70 , Tnfsf9, Ptgs2 and Bcl2l1 , and examined their contributions to...

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Veröffentlicht in:	Nature immunology 2022-11, Vol.23 (11), p.1536-1550
Hauptverfasser:	Wu, Renee, Ohara, Ray A., Jo, Suin, Liu, Tian-Tian, Ferris, Stephen T., Ou, Feiya, Kim, Sunkyung, Theisen, Derek J., Anderson, David A., Wong, Brian W., Gershon, Timothy, Schreiber, Robert D., Murphy, Theresa L., Murphy, Kenneth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1932 631/250/21/1293 631/250/2504/133/2505 631/250/580 Animals Antigen Presentation Biomedical and Life Sciences Biomedicine Caspase CD27 antigen CD4 antigen CD40 antigen CD40 Antigens - genetics CD70 antigen CD8 antigen CD8-Positive T-Lymphocytes Dendritic Cells Gene expression Immunology Inactivation Infectious Diseases Lymph nodes Lymphocytes Lymphocytes T Membrane potential Mice Mice, Inbred C57BL Mitochondria Neoplasms Tumors
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