Lipopolysaccharide Structure and the Phenomenon of Low Endotoxin Recovery

Graphical Abstract Caption: When purified LPS is spiked, as an assay control, into an undiluted drug product which also contains chelating agent and surfactant, over time the LPS can be masked from detection by the LAL-assay, which is the gold-standard industrial LPS detection method. This raises a...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2022-11, Vol.180, p.289-307
Hauptverfasser:	Gorman, Amy, Golovanov, Alexander P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Core Limulus Amebocyte Lysate (LAL) Assay Lipid A Lipopolysaccharide Low Endotoxin Recovery LPS Aggregation Masking O-antigen Structure Supramolecular TLR4-MD2 Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!