Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer’s Disease Biomarkers
Background: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer’s Disease (AD) could help to clarify the role of depression and SI in AD...
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| Veröffentlicht in: | Psicothema 2022-11, Vol.34 (4), p.553-561 |
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| creator | Ferrer-Cairols, Inés Baquero, Miguel Salvador, Alicia Montoliu, Teresa Crespo-Sanmiguel, Isabel Pulopulos, Matias Hidalgo, Vanesa Gómez, Enriqueta López-Cuevas, Rogelio Cuevas, Ana Martín, Núria |
| description | Background: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer’s Disease (AD) could help to clarify the role of depression and SI in AD. Method: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-ß (Aß), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed. Results: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide. Conclusions: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms. Depresión y Riesgo de Suicidio en el Deterioro Cognitivo Leve: el Rol de los Biomarcadores de la Enfermedad de Alzheimer. Antecedentes: Los pacientes con depresión y deterioro cognitivo leve (DCL) tienen un alto riesgo de desarrollar demencia. La depresión implica un alto riesgo de ideación suicida (IS) e intentos de suicidio (AS). Los biomarcadores de la enfermedad de Alzheimer (EA) pueden clarificar el papel de la depresión e IS en la EA. Método: Cincuenta y nueve participantes >50 años con criterios de DCL-EA positivo (DCL-EA; 22) y negativo (DCL-NoEA; 24) y 13 controles sanos. La depresión fue evaluada con la Escala Geriátrica de Depresión (GDS-30) y la IS con el factor GDS-IS. Además, se midieron los siguientes biomarcadores en el líquido cefalorraquídeo: ß-amiloide (ß-A), tau hiperfosforilada (H-tau) y total (T-tau). Resultados: No se encontraron diferencias significativas entre los tres grupos de participantes en depresión o en IS. Sin embargo, en el grupo DCL-EA, niveles más bajos de H-tau y T-tau, indicadores de menor patología EA, se relacionaron significativamente con mayor riesgo de suicidio indirecto. Conclusiones: Este resultado subraya la importancia de considerar la IS en fases iniciales de EA, y el potencial papel de los biomarcadores de EA para detectar sus sínto |
| doi_str_mv | 10.7334/psicothema2022.103 |
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Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer’s Disease (AD) could help to clarify the role of depression and SI in AD. Method: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-ß (Aß), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed. Results: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide. Conclusions: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms. Depresión y Riesgo de Suicidio en el Deterioro Cognitivo Leve: el Rol de los Biomarcadores de la Enfermedad de Alzheimer. Antecedentes: Los pacientes con depresión y deterioro cognitivo leve (DCL) tienen un alto riesgo de desarrollar demencia. La depresión implica un alto riesgo de ideación suicida (IS) e intentos de suicidio (AS). Los biomarcadores de la enfermedad de Alzheimer (EA) pueden clarificar el papel de la depresión e IS en la EA. Método: Cincuenta y nueve participantes >50 años con criterios de DCL-EA positivo (DCL-EA; 22) y negativo (DCL-NoEA; 24) y 13 controles sanos. La depresión fue evaluada con la Escala Geriátrica de Depresión (GDS-30) y la IS con el factor GDS-IS. Además, se midieron los siguientes biomarcadores en el líquido cefalorraquídeo: ß-amiloide (ß-A), tau hiperfosforilada (H-tau) y total (T-tau). Resultados: No se encontraron diferencias significativas entre los tres grupos de participantes en depresión o en IS. Sin embargo, en el grupo DCL-EA, niveles más bajos de H-tau y T-tau, indicadores de menor patología EA, se relacionaron significativamente con mayor riesgo de suicidio indirecto. Conclusiones: Este resultado subraya la importancia de considerar la IS en fases iniciales de EA, y el potencial papel de los biomarcadores de EA para detectar sus síntomas.</description><identifier>ISSN: 0214-9915</identifier><identifier>EISSN: 1886-144X</identifier><identifier>DOI: 10.7334/psicothema2022.103</identifier><language>eng</language><publisher>Oviedo: Colegio Oficial de Psicólogos (PSICODOC)</publisher><subject>Alzheimer's disease ; Biomarkers ; Cognitive ability ; Mental depression ; Suicides & suicide attempts</subject><ispartof>Psicothema, 2022-11, Vol.34 (4), p.553-561</ispartof><rights>2022. Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the associated terms available at https://www.psicothema.com/PublicationNorms2022.pdf</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c238t-857b23a75ce8b5fe8a95afbe5beae77eb936cbbceba75a1aecfa3c92d08596a73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2778310170/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2778310170?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,12725,12754,21368,21369,21370,21371,21372,23236,27903,27904,33431,33432,33509,33510,33682,33683,33723,33724,33984,33985,34293,34294,34313,34314,36244,36245,43595,43638,43766,43784,43932,44046,44052,44383,64361,64363,64365,72215,73797,73850,74029,74048,74219,74336,74342,74682</link.rule.ids></links><search><creatorcontrib>Ferrer-Cairols, Inés</creatorcontrib><creatorcontrib>Baquero, Miguel</creatorcontrib><creatorcontrib>Salvador, Alicia</creatorcontrib><creatorcontrib>Montoliu, Teresa</creatorcontrib><creatorcontrib>Crespo-Sanmiguel, Isabel</creatorcontrib><creatorcontrib>Pulopulos, Matias</creatorcontrib><creatorcontrib>Hidalgo, Vanesa</creatorcontrib><creatorcontrib>Gómez, Enriqueta</creatorcontrib><creatorcontrib>López-Cuevas, Rogelio</creatorcontrib><creatorcontrib>Cuevas, Ana</creatorcontrib><creatorcontrib>Martín, Núria</creatorcontrib><title>Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer’s Disease Biomarkers</title><title>Psicothema</title><description>Background: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer’s Disease (AD) could help to clarify the role of depression and SI in AD. Method: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-ß (Aß), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed. Results: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide. Conclusions: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms. Depresión y Riesgo de Suicidio en el Deterioro Cognitivo Leve: el Rol de los Biomarcadores de la Enfermedad de Alzheimer. Antecedentes: Los pacientes con depresión y deterioro cognitivo leve (DCL) tienen un alto riesgo de desarrollar demencia. La depresión implica un alto riesgo de ideación suicida (IS) e intentos de suicidio (AS). Los biomarcadores de la enfermedad de Alzheimer (EA) pueden clarificar el papel de la depresión e IS en la EA. Método: Cincuenta y nueve participantes >50 años con criterios de DCL-EA positivo (DCL-EA; 22) y negativo (DCL-NoEA; 24) y 13 controles sanos. La depresión fue evaluada con la Escala Geriátrica de Depresión (GDS-30) y la IS con el factor GDS-IS. Además, se midieron los siguientes biomarcadores en el líquido cefalorraquídeo: ß-amiloide (ß-A), tau hiperfosforilada (H-tau) y total (T-tau). Resultados: No se encontraron diferencias significativas entre los tres grupos de participantes en depresión o en IS. Sin embargo, en el grupo DCL-EA, niveles más bajos de H-tau y T-tau, indicadores de menor patología EA, se relacionaron significativamente con mayor riesgo de suicidio indirecto. Conclusiones: Este resultado subraya la importancia de considerar la IS en fases iniciales de EA, y el potencial papel de los biomarcadores de EA para detectar sus síntomas.</description><subject>Alzheimer's disease</subject><subject>Biomarkers</subject><subject>Cognitive ability</subject><subject>Mental depression</subject><subject>Suicides & suicide attempts</subject><issn>0214-9915</issn><issn>1886-144X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0MtKw0AUBuBBFKzVF3A14MZN6lySzMRdbb0UKoJWcBdmpid22iQTZxJBV76Gr-eTGKkbXR04fBzO_yN0TMlIcB6fNcEa166gUowwNqKE76ABlTKNaBw_7aIBYTSOsowm--gghDUhScoFG6BiCo2HEKyrsaqX-KGzxi4B39uwwbbGt7Zc4ol7rm1rXwHPqkZZX0HdnuPFqmeuBOwKPC7fV2Ar8F8fnwFPbQAVAF9YVym_AR8O0V6hygBHv3OIHq8uF5ObaH53PZuM55FhXLaRTIRmXInEgNRJAVJliSo0JBoUCAE646nR2oDujaIKTKG4ydiSyCRLleBDdLq923j30kFo88oGA2WpanBdyJlgog-ekR968o-uXefr_rteCckpoYL0im2V8S4ED0XeeNuHesspyX-qz_9W3685_wanV3yJ</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Ferrer-Cairols, Inés</creator><creator>Baquero, Miguel</creator><creator>Salvador, Alicia</creator><creator>Montoliu, Teresa</creator><creator>Crespo-Sanmiguel, Isabel</creator><creator>Pulopulos, Matias</creator><creator>Hidalgo, Vanesa</creator><creator>Gómez, Enriqueta</creator><creator>López-Cuevas, Rogelio</creator><creator>Cuevas, Ana</creator><creator>Martín, Núria</creator><general>Colegio Oficial de Psicólogos (PSICODOC)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20221101</creationdate><title>Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer’s Disease Biomarkers</title><author>Ferrer-Cairols, Inés ; Baquero, Miguel ; Salvador, Alicia ; Montoliu, Teresa ; Crespo-Sanmiguel, Isabel ; Pulopulos, Matias ; Hidalgo, Vanesa ; Gómez, Enriqueta ; López-Cuevas, Rogelio ; Cuevas, Ana ; Martín, Núria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c238t-857b23a75ce8b5fe8a95afbe5beae77eb936cbbceba75a1aecfa3c92d08596a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Biomarkers</topic><topic>Cognitive ability</topic><topic>Mental depression</topic><topic>Suicides & suicide attempts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrer-Cairols, Inés</creatorcontrib><creatorcontrib>Baquero, Miguel</creatorcontrib><creatorcontrib>Salvador, Alicia</creatorcontrib><creatorcontrib>Montoliu, Teresa</creatorcontrib><creatorcontrib>Crespo-Sanmiguel, Isabel</creatorcontrib><creatorcontrib>Pulopulos, Matias</creatorcontrib><creatorcontrib>Hidalgo, Vanesa</creatorcontrib><creatorcontrib>Gómez, Enriqueta</creatorcontrib><creatorcontrib>López-Cuevas, Rogelio</creatorcontrib><creatorcontrib>Cuevas, Ana</creatorcontrib><creatorcontrib>Martín, Núria</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psicothema</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrer-Cairols, Inés</au><au>Baquero, Miguel</au><au>Salvador, Alicia</au><au>Montoliu, Teresa</au><au>Crespo-Sanmiguel, Isabel</au><au>Pulopulos, Matias</au><au>Hidalgo, Vanesa</au><au>Gómez, Enriqueta</au><au>López-Cuevas, Rogelio</au><au>Cuevas, Ana</au><au>Martín, Núria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer’s Disease Biomarkers</atitle><jtitle>Psicothema</jtitle><date>2022-11-01</date><risdate>2022</risdate><volume>34</volume><issue>4</issue><spage>553</spage><epage>561</epage><pages>553-561</pages><issn>0214-9915</issn><eissn>1886-144X</eissn><abstract>Background: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer’s Disease (AD) could help to clarify the role of depression and SI in AD. Method: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-ß (Aß), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed. Results: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide. Conclusions: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms. Depresión y Riesgo de Suicidio en el Deterioro Cognitivo Leve: el Rol de los Biomarcadores de la Enfermedad de Alzheimer. Antecedentes: Los pacientes con depresión y deterioro cognitivo leve (DCL) tienen un alto riesgo de desarrollar demencia. La depresión implica un alto riesgo de ideación suicida (IS) e intentos de suicidio (AS). Los biomarcadores de la enfermedad de Alzheimer (EA) pueden clarificar el papel de la depresión e IS en la EA. Método: Cincuenta y nueve participantes >50 años con criterios de DCL-EA positivo (DCL-EA; 22) y negativo (DCL-NoEA; 24) y 13 controles sanos. La depresión fue evaluada con la Escala Geriátrica de Depresión (GDS-30) y la IS con el factor GDS-IS. Además, se midieron los siguientes biomarcadores en el líquido cefalorraquídeo: ß-amiloide (ß-A), tau hiperfosforilada (H-tau) y total (T-tau). Resultados: No se encontraron diferencias significativas entre los tres grupos de participantes en depresión o en IS. Sin embargo, en el grupo DCL-EA, niveles más bajos de H-tau y T-tau, indicadores de menor patología EA, se relacionaron significativamente con mayor riesgo de suicidio indirecto. Conclusiones: Este resultado subraya la importancia de considerar la IS en fases iniciales de EA, y el potencial papel de los biomarcadores de EA para detectar sus síntomas.</abstract><cop>Oviedo</cop><pub>Colegio Oficial de Psicólogos (PSICODOC)</pub><doi>10.7334/psicothema2022.103</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer's disease Biomarkers Cognitive ability Mental depression Suicides & suicide attempts |
| title | Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer’s Disease Biomarkers |
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