Three-Input Logic AND Gate Drives Sequential Three-Step Catalysis by Parallel Activation of H+ and Ag+ as a Catalyst Duo

Boolean operations with multiple catalysts as output are yet unknown using molecular logic. The issue is solved using a two-component ensemble, composed of a receptor and rotaxane, which acts as a three-input AND gate with a dual catalytic output. Actuation of the ensemble gate by the stoichiometric addition of metal ions (Ag+ and Cd2+) and 2,2,2-trifluoroacetic acid generated in the (1,1,1) truth table state a catalyst duo that synergistically enabled a three-step reaction, furnishing a dihydroisoquinoline as the output of a three-input logic AND gate operation.