Transcriptional Control of Peripheral Nerve Regeneration
Transcription factors are master regulators of various cellular processes under diverse physiological and pathological conditions. Many transcription factors that are differentially expressed after injury to peripheral nerves play important roles in nerve regeneration. Considering that rapid and tim...
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| Veröffentlicht in: | Molecular neurobiology 2023, Vol.60 (1), p.329-341 |
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| creator | Zhang, Yunsong Zhao, Qian Chen, Qianqian Xu, Lingchi Yi, Sheng |
| description | Transcription factors are master regulators of various cellular processes under diverse physiological and pathological conditions. Many transcription factors that are differentially expressed after injury to peripheral nerves play important roles in nerve regeneration. Considering that rapid and timely regrowth of injured axons is a prerequisite for successful target reinnervation, here, we compile transcription factors that mediates axon elongation, including axon growth suppressor Klf4 and axon growth promoters c-Myc, Sox11, STAT3, Atf3, c-Jun, Smad1, C/EBPδ, and p53. Besides neuronal changes, Schwann cell phenotype modulation is also critical for nerve regeneration. The activation of Schwann cells at early time points post injury provides a permissive microenvironment whereas the re-differentiation of Schwann cells at later time points supports myelin sheath formation. Hence, c-Jun and Sox2, two critical drivers for Schwann cell reprogramming, as well as Krox-20 and Sox10, two essential regulators of Schwann cell myelination, are reviewed. These transcription factors may serve as promising targets for promoting the functional recovery of injured peripheral nerves. |
| doi_str_mv | 10.1007/s12035-022-03090-0 |
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Many transcription factors that are differentially expressed after injury to peripheral nerves play important roles in nerve regeneration. Considering that rapid and timely regrowth of injured axons is a prerequisite for successful target reinnervation, here, we compile transcription factors that mediates axon elongation, including axon growth suppressor Klf4 and axon growth promoters c-Myc, Sox11, STAT3, Atf3, c-Jun, Smad1, C/EBPδ, and p53. Besides neuronal changes, Schwann cell phenotype modulation is also critical for nerve regeneration. The activation of Schwann cells at early time points post injury provides a permissive microenvironment whereas the re-differentiation of Schwann cells at later time points supports myelin sheath formation. Hence, c-Jun and Sox2, two critical drivers for Schwann cell reprogramming, as well as Krox-20 and Sox10, two essential regulators of Schwann cell myelination, are reviewed. These transcription factors may serve as promising targets for promoting the functional recovery of injured peripheral nerves.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-022-03090-0</identifier><identifier>PMID: 36261692</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Activating transcription factor 3 ; Axon guidance ; Biomedical and Life Sciences ; Biomedicine ; c-Jun protein ; c-Myc protein ; Cell activation ; Cell Biology ; Cell differentiation ; KLF4 protein ; Krox-20 protein ; Microenvironments ; Myc protein ; Myelination ; Nervous system ; Neurobiology ; Neurology ; Neurosciences ; Peripheral nerves ; Phenotypes ; Recovery of function ; Regeneration ; Reinnervation ; Schwann cells ; Sox10 protein ; Stat3 protein ; Transcription factors</subject><ispartof>Molecular neurobiology, 2023, Vol.60 (1), p.329-341</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. 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Many transcription factors that are differentially expressed after injury to peripheral nerves play important roles in nerve regeneration. Considering that rapid and timely regrowth of injured axons is a prerequisite for successful target reinnervation, here, we compile transcription factors that mediates axon elongation, including axon growth suppressor Klf4 and axon growth promoters c-Myc, Sox11, STAT3, Atf3, c-Jun, Smad1, C/EBPδ, and p53. Besides neuronal changes, Schwann cell phenotype modulation is also critical for nerve regeneration. The activation of Schwann cells at early time points post injury provides a permissive microenvironment whereas the re-differentiation of Schwann cells at later time points supports myelin sheath formation. Hence, c-Jun and Sox2, two critical drivers for Schwann cell reprogramming, as well as Krox-20 and Sox10, two essential regulators of Schwann cell myelination, are reviewed. These transcription factors may serve as promising targets for promoting the functional recovery of injured peripheral nerves.</description><subject>Activating transcription factor 3</subject><subject>Axon guidance</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>c-Jun protein</subject><subject>c-Myc protein</subject><subject>Cell activation</subject><subject>Cell Biology</subject><subject>Cell differentiation</subject><subject>KLF4 protein</subject><subject>Krox-20 protein</subject><subject>Microenvironments</subject><subject>Myc protein</subject><subject>Myelination</subject><subject>Nervous system</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Peripheral nerves</subject><subject>Phenotypes</subject><subject>Recovery of function</subject><subject>Regeneration</subject><subject>Reinnervation</subject><subject>Schwann cells</subject><subject>Sox10 protein</subject><subject>Stat3 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Control of Peripheral Nerve Regeneration</title><author>Zhang, Yunsong ; Zhao, Qian ; Chen, Qianqian ; Xu, Lingchi ; Yi, Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7dc343b2f2ddd9b156220f56f0e3ace3f1339b6ccf1b8f027bc6ac90b73479603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Activating transcription factor 3</topic><topic>Axon guidance</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>c-Jun protein</topic><topic>c-Myc protein</topic><topic>Cell activation</topic><topic>Cell Biology</topic><topic>Cell differentiation</topic><topic>KLF4 protein</topic><topic>Krox-20 protein</topic><topic>Microenvironments</topic><topic>Myc protein</topic><topic>Myelination</topic><topic>Nervous system</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Peripheral nerves</topic><topic>Phenotypes</topic><topic>Recovery of function</topic><topic>Regeneration</topic><topic>Reinnervation</topic><topic>Schwann cells</topic><topic>Sox10 protein</topic><topic>Stat3 protein</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yunsong</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Chen, Qianqian</creatorcontrib><creatorcontrib>Xu, Lingchi</creatorcontrib><creatorcontrib>Yi, Sheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni 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Neurobiol</addtitle><date>2023</date><risdate>2023</risdate><volume>60</volume><issue>1</issue><spage>329</spage><epage>341</epage><pages>329-341</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Transcription factors are master regulators of various cellular processes under diverse physiological and pathological conditions. Many transcription factors that are differentially expressed after injury to peripheral nerves play important roles in nerve regeneration. Considering that rapid and timely regrowth of injured axons is a prerequisite for successful target reinnervation, here, we compile transcription factors that mediates axon elongation, including axon growth suppressor Klf4 and axon growth promoters c-Myc, Sox11, STAT3, Atf3, c-Jun, Smad1, C/EBPδ, and p53. Besides neuronal changes, Schwann cell phenotype modulation is also critical for nerve regeneration. The activation of Schwann cells at early time points post injury provides a permissive microenvironment whereas the re-differentiation of Schwann cells at later time points supports myelin sheath formation. Hence, c-Jun and Sox2, two critical drivers for Schwann cell reprogramming, as well as Krox-20 and Sox10, two essential regulators of Schwann cell myelination, are reviewed. These transcription factors may serve as promising targets for promoting the functional recovery of injured peripheral nerves.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36261692</pmid><doi>10.1007/s12035-022-03090-0</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-1316-3370</orcidid></addata></record> |
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| subjects | Activating transcription factor 3 Axon guidance Biomedical and Life Sciences Biomedicine c-Jun protein c-Myc protein Cell activation Cell Biology Cell differentiation KLF4 protein Krox-20 protein Microenvironments Myc protein Myelination Nervous system Neurobiology Neurology Neurosciences Peripheral nerves Phenotypes Recovery of function Regeneration Reinnervation Schwann cells Sox10 protein Stat3 protein Transcription factors |
| title | Transcriptional Control of Peripheral Nerve Regeneration |
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