Synthesis of a Bifunctional Cross-Bridged Chelating Agent, Peptide Conjugation, and Comparison of 68 Ga Labeling and Complex Stability Characteristics with Established Chelators

[ Ga]Ga can be introduced into receptor-specific peptidic carriers via different chelators to obtain radiotracers for Positron Emission Tomography imaging and the chosen chelating agent considerably influences the in vivo pharmacokinetics of the corresponding radiopeptides. A chelator that should be...

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Veröffentlicht in:	ChemMedChem 2023-01, Vol.18 (1), p.e202200495
Hauptverfasser:	Damerow, Helen, Wängler, Björn, Schirrmacher, Ralf, Fricker, Gert, Wängler, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Chelating Agents Peptides Peptides, Cyclic - metabolism Positron-Emission Tomography - methods
Online-Zugang:	Volltext
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