Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage

Phosphodiesterase 3A ( ) gain-of-function mutations cause hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular resistance, rather than salt retention, is responsible. It is surprising that the few patients with HTNB examined so far did not develop cardiac hypertro...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2022-12, Vol.146 (23), p.1758-1778
Hauptverfasser:	Ercu, Maria, Mücke, Michael B., Pallien, Tamara, Markó, Lajos, Sholokh, Anastasiia, Schächterle, Carolin, Aydin, Atakan, Kidd, Alexa, Walter, Stephan, Esmati, Yasmin, McMurray, Brandon J., Lato, Daniella F., Yumi Sunaga-Franze, Daniele, Dierks, Philip H., Flores, Barbara Isabel Montesinos, Walker-Gray, Ryan, Gong, Maolian, Merticariu, Claudia, Zühlke, Kerstin, Russwurm, Michael, Liu, Tiannan, Batolomaeus, Theda U.P., Pautz, Sabine, Schelenz, Stefanie, Taube, Martin, Napieczynska, Hanna, Heuser, Arnd, Eichhorst, Jenny, Lehmann, Martin, Miller, Duncan C., Diecke, Sebastian, Qadri, Fatimunnisa, Popova, Elena, Langanki, Reika, Movsesian, Matthew A., Herberg, Friedrich W., Forslund, Sofia K., Müller, Dominik N., Borodina, Tatiana, Maass, Philipp G., Bähring, Sylvia, Hübner, Norbert, Bader, Michael, Klussmann, Enno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism Heart Failure Humans Hypertension - complications Hypertension - genetics Induced Pluripotent Stem Cells - metabolism Myocytes, Cardiac - metabolism Rats RNA X-Ray Microtomography
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