Computational biophysics approach towards the discovery of multi-kinase blockers for the management of MAPK pathway dysregulation

The MAPK pathway is important in human lung cancer and is improperly activated in a substantial proportion through number of ways. Strategies on dual-targeting RAF and MEK are an alternative option to diminish the limitations in this pathway inhibition. Hence, we implemented parallel pharmacophore s...

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Veröffentlicht in:	Molecular diversity 2023-10, Vol.27 (5), p.2093-2110
Hauptverfasser:	Thirunavukkarasu, Muthu Kumar, Veerappapillai, Shanthi, Karuppasamy, Ramanathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Life Sciences Lung cancer Organic Chemistry Original Article Pharmacy Polymer Sciences
Online-Zugang:	Volltext
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