CRISPR/Cas9-induced knockout reveals the role of ABCB1 in the response to temozolomide, carmustine and lomustine in glioblastoma multiforme

Glioblastoma multiforme (GBM) is the most common malignant brain tumor with limited therapeutic options. Besides surgery, chemotherapy using temozolomide, carmustine or lomustine is the main pillar of therapy. However, therapy success is limited and prognosis still is very poor. One restraining fact...

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Veröffentlicht in:	Pharmacological research 2022-11, Vol.185, p.106510-106510, Article 106510
Hauptverfasser:	Radtke, Lena, Majchrzak-Celińska, Aleksandra, Awortwe, Charles, Vater, Inga, Nagel, Inga, Sebens, Susanne, Cascorbi, Ingolf, Kaehler, Meike
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters CRISPR Drug resistance Glioblastoma Temozolomide
Online-Zugang:	Volltext
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