Estrogenic, androgenic, and glucocorticoid activities and major causative compounds in river waters from three Asian countries
Estrogen, androgen, and glucocorticoid receptors (ER, AR, and GR) agonist activities in river water samples from Chennai and Bangalore (India), Jakarta (Indonesia), and Hanoi (Vietnam) were evaluated using a panel of chemical-activated luciferase gene expression (CALUX) assays and were detected main...
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| Veröffentlicht in: | Environmental science and pollution research international 2023-02, Vol.30 (8), p.20765-20774 |
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| creator | Tue, Nguyen Minh Matsukami, Hidenori Tuyen, Le Huu Suzuki, Go Viet, Pham Hung Sudaryanto, Agus Subramanian, Annamalai Tanabe, Shinsuke Kunisue, Tatsuya |
| description | Estrogen, androgen, and glucocorticoid receptors (ER, AR, and GR) agonist activities in river water samples from Chennai and Bangalore (India), Jakarta (Indonesia), and Hanoi (Vietnam) were evaluated using a panel of chemical-activated luciferase gene expression (CALUX) assays and were detected mainly in the dissolved phase. The ER agonist activity levels were 0.011–55 ng estradiol (E2)-equivalent/l, higher than the proposed effect-based trigger (EBT) value of 0.5 ng/l in most of the samples. The AR agonist activity levels were |
| doi_str_mv | 10.1007/s11356-022-23674-6 |
| format | Article |
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The ER agonist activity levels were 0.011–55 ng estradiol (E2)-equivalent/l, higher than the proposed effect-based trigger (EBT) value of 0.5 ng/l in most of the samples. The AR agonist activity levels were < 2.1–110 ng dihydrotestosterone (DHT)-equivalent/l, and all levels above the limit of quantification exceeded the EBT value of 3.4 ng/l. GR agonist activities were detected in only Bangalore and Hanoi samples at dexamethasone (Dex)-equivalent levels of < 16–150 ng/l and exceeded the EBT value of 100 ng/l in only two Bangalore samples. Major compounds contributing to the ER, AR, and GR agonist activities were identified for water samples from Bangalore and Hanoi, which had substantially higher activities in all assays, by using a combination of fractionation, CALUX measurement, and non-target and target chemical analysis. The results for pooled samples showed that the major ER agonists were the endogenous estrogens E2 and estriol, and the major GR agonists were the synthetic glucocorticoids Dex and clobetasol propionate. The only AR agonist identified in major androgenic water extract fractions was DHT, but several unidentified compounds with the same molecular formulae as endogenous androgens were also found.</description><identifier>ISSN: 1614-7499</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-022-23674-6</identifier><identifier>PMID: 36255587</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Androgens - analysis ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Biological Assay - methods ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Estrogens - analysis ; Estrone - analysis ; Glucocorticoids - analysis ; India ; Indonesia ; Research Article ; Rivers - chemistry ; Vietnam ; Waste Water Technology ; Water - analysis ; Water Management ; Water Pollutants, Chemical - analysis ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2023-02, Vol.30 (8), p.20765-20774</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-490aaf77de6ad728c0823942205802bdc159116b3f23c8a84c99c069210a75ac3</citedby><cites>FETCH-LOGICAL-c413t-490aaf77de6ad728c0823942205802bdc159116b3f23c8a84c99c069210a75ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-022-23674-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-022-23674-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36255587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tue, Nguyen Minh</creatorcontrib><creatorcontrib>Matsukami, Hidenori</creatorcontrib><creatorcontrib>Tuyen, Le Huu</creatorcontrib><creatorcontrib>Suzuki, Go</creatorcontrib><creatorcontrib>Viet, Pham Hung</creatorcontrib><creatorcontrib>Sudaryanto, Agus</creatorcontrib><creatorcontrib>Subramanian, Annamalai</creatorcontrib><creatorcontrib>Tanabe, Shinsuke</creatorcontrib><creatorcontrib>Kunisue, Tatsuya</creatorcontrib><title>Estrogenic, androgenic, and glucocorticoid activities and major causative compounds in river waters from three Asian countries</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Estrogen, androgen, and glucocorticoid receptors (ER, AR, and GR) agonist activities in river water samples from Chennai and Bangalore (India), Jakarta (Indonesia), and Hanoi (Vietnam) were evaluated using a panel of chemical-activated luciferase gene expression (CALUX) assays and were detected mainly in the dissolved phase. The ER agonist activity levels were 0.011–55 ng estradiol (E2)-equivalent/l, higher than the proposed effect-based trigger (EBT) value of 0.5 ng/l in most of the samples. The AR agonist activity levels were < 2.1–110 ng dihydrotestosterone (DHT)-equivalent/l, and all levels above the limit of quantification exceeded the EBT value of 3.4 ng/l. GR agonist activities were detected in only Bangalore and Hanoi samples at dexamethasone (Dex)-equivalent levels of < 16–150 ng/l and exceeded the EBT value of 100 ng/l in only two Bangalore samples. Major compounds contributing to the ER, AR, and GR agonist activities were identified for water samples from Bangalore and Hanoi, which had substantially higher activities in all assays, by using a combination of fractionation, CALUX measurement, and non-target and target chemical analysis. The results for pooled samples showed that the major ER agonists were the endogenous estrogens E2 and estriol, and the major GR agonists were the synthetic glucocorticoids Dex and clobetasol propionate. The only AR agonist identified in major androgenic water extract fractions was DHT, but several unidentified compounds with the same molecular formulae as endogenous androgens were also found.</description><subject>Androgens - analysis</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biological Assay - methods</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Estrogens - analysis</subject><subject>Estrone - analysis</subject><subject>Glucocorticoids - analysis</subject><subject>India</subject><subject>Indonesia</subject><subject>Research Article</subject><subject>Rivers - chemistry</subject><subject>Vietnam</subject><subject>Waste Water Technology</subject><subject>Water - analysis</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollution Control</subject><issn>1614-7499</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOAzEQRS0EIrx-gAK5pGDBb69LhHhJSDRQW47XGxxl7WB7QTR8OyYJiIpqRjNnrjQHgGOMzjFC8iJjTLloECENoUKyRmyBPSwwayRTavtPPwH7Oc8RIkgRuQsmVBDOeSv3wOd1LinOXPD2DJrQ_e3hbDHaaGMq3kbfQWOLf_PFu7zaDmYeE7RmzKbOHbRxWMYxdBn6AFOdJPhuiksZ9ikOsLwk5-Bl9iZUdAwl1aBDsNObRXZHm3oAnm-un67umofH2_ury4fGMkxLwxQyppeyc8J0krQWtYQqRgjiLSLTzmKuMBZT2hNqW9Myq5RFQhGMjOTG0gNwus5dpvg6ulz04LN1i4UJLo5ZE0m44JhhVlGyRm2KOSfX62Xyg0kfGiP97V2vvevqXa-8a1GPTjb543Rw3e_Jj-gK0DWQ6yrMXNLzOKZQf_4v9gtSG4-9</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Tue, Nguyen Minh</creator><creator>Matsukami, Hidenori</creator><creator>Tuyen, Le Huu</creator><creator>Suzuki, Go</creator><creator>Viet, Pham Hung</creator><creator>Sudaryanto, Agus</creator><creator>Subramanian, Annamalai</creator><creator>Tanabe, Shinsuke</creator><creator>Kunisue, Tatsuya</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230201</creationdate><title>Estrogenic, androgenic, and glucocorticoid activities and major causative compounds in river waters from three Asian countries</title><author>Tue, Nguyen Minh ; 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The ER agonist activity levels were 0.011–55 ng estradiol (E2)-equivalent/l, higher than the proposed effect-based trigger (EBT) value of 0.5 ng/l in most of the samples. The AR agonist activity levels were < 2.1–110 ng dihydrotestosterone (DHT)-equivalent/l, and all levels above the limit of quantification exceeded the EBT value of 3.4 ng/l. GR agonist activities were detected in only Bangalore and Hanoi samples at dexamethasone (Dex)-equivalent levels of < 16–150 ng/l and exceeded the EBT value of 100 ng/l in only two Bangalore samples. Major compounds contributing to the ER, AR, and GR agonist activities were identified for water samples from Bangalore and Hanoi, which had substantially higher activities in all assays, by using a combination of fractionation, CALUX measurement, and non-target and target chemical analysis. The results for pooled samples showed that the major ER agonists were the endogenous estrogens E2 and estriol, and the major GR agonists were the synthetic glucocorticoids Dex and clobetasol propionate. The only AR agonist identified in major androgenic water extract fractions was DHT, but several unidentified compounds with the same molecular formulae as endogenous androgens were also found.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36255587</pmid><doi>10.1007/s11356-022-23674-6</doi><tpages>10</tpages></addata></record> |
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| subjects | Androgens - analysis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Biological Assay - methods Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Estrogens - analysis Estrone - analysis Glucocorticoids - analysis India Indonesia Research Article Rivers - chemistry Vietnam Waste Water Technology Water - analysis Water Management Water Pollutants, Chemical - analysis Water Pollution Control |
| title | Estrogenic, androgenic, and glucocorticoid activities and major causative compounds in river waters from three Asian countries |
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