Drug-Carrier Miscibility in Solid Dispersions of Glibenclamide and a Novel Approach to Enhance Its Solubility Using an Effervescent Agent

The present research aims to investigate the miscibility, physical stability, solubility, and dissolution rate of a poorly water-soluble glibenclamide (GLB) in solid dispersions (SDs) with hydrophilic carriers like PEG-1500 and PEG-50 hydrogenated palm glycerides (Acconon). Mathematical theories suc...

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Veröffentlicht in:	AAPS PharmSciTech 2022-10, Vol.23 (8), p.284-284, Article 284
Hauptverfasser:	Pisay, Muralidhar, Bhaskar, K. Vijaya, Mehta, Chetan Hasmukh, Nayak, Usha Yogendra, Koteshwara, Kunnatur Balasundara, Mutalik, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Pharmacology/Toxicology Pharmacy Research Article Theme: Advancements in Amorphous Solid Dispersions to Improve Bioavailability
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