Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF

Abstract Objective HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. While extensive genetic analyses have been conducted to generate a detailed profile of ACPA, a...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2023-05, Vol.62 (5), p.2015-2020
Hauptverfasser:	Yaku, Ai, Ishikawa, Yuki, Iwasaki, Takeshi, Hiwa, Ryosuke, Matsuo, Keitaro, Saji, Hiroh, Yurugi, Kimiko, Miura, Yasuo, Furu, Moritoshi, Ito, Hiromu, Fujii, Takao, Maekawa, Taira, Hashimoto, Motomu, Ohmura, Koichiro, Mimori, Tsuneyo, Terao, Chikashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arthritis, Rheumatoid Autoantibodies Epitopes Genetic Predisposition to Disease Genotype HLA-DRB1 Chains - genetics Humans Immunoglobulin G Immunoglobulin M Peptides, Cyclic Rheumatoid Factor
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