DNA opening during transcription initiation by RNA polymerase II in atomic detail

RNA polymerase II (RNAP II) synthesizes RNA by reading the DNA code. During transcription initiation, RNAP II opens the double-stranded DNA to expose the DNA template to the active site. The molecular interactions driving and controlling DNA opening are not well understood. We used all-atom steered...

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Veröffentlicht in:	Biophysical journal 2022-11, Vol.121 (22), p.4299-4310
Hauptverfasser:	Lapierre, Jeremy, Hub, Jochen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - metabolism DNA-Directed RNA Polymerases - metabolism Humans Promoter Regions, Genetic RNA Polymerase II - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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