Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase

Ferroptosis is a novel form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxides to lethal levels, which is morphologically, biochemically, and genetically distinct from apoptosis, necroptosis, autophagy, and pyroptosis. Manganese play an important role in inna...

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Veröffentlicht in:	Free radical biology & medicine 2022-11, Vol.193 (Pt 1), p.202-212
Hauptverfasser:	Zhang, Shanlong, Kang, Li, Dai, Xiaoxue, Chen, Junlan, Chen, Zhengtao, Wang, Meixiang, Jiang, Huantong, Wang, Xin, Bu, Suqin, Liu, Xinyuan, Zhang, Guohui, Tang, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	cGAS–STING DHODH Dihydroorotate Dehydrogenase Ferroptosis Ferroptosis - genetics Lipid peroxidation Manganese - pharmacology Nucleotidyltransferases - metabolism Reactive Oxygen Species - metabolism Type-I IFN
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