SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor

Dihydroorotate dehydrogenase (DHODH) is the enzyme that catalyzes a rate-determining step during the de novo synthesis of uridine, an important source of cellular pyrimidine nucleotides. Ability to modulate the activity of this enzyme may be used to control diseases associated with rapid, out-of-con...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-12, Vol.244, p.114826-114826, Article 114826
Hauptverfasser:	Baiazitov, Ramil Y., Qi, Hongyan, Arasu, Tamil, Lennox, William, Cao, Liangxian, Weetall, Marla, Furia, Bansri, Zhuo, Jin, Choi, Soongyu, Kim, Min Jung, Sheedy, Josephine, Davis, Thomas, Moon, Young-Choon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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