Global, in situ analysis of the structural proteome in individuals with Parkinson’s disease to identify a new class of biomarker

Parkinson’s disease (PD) is a prevalent neurodegenerative disease for which robust biomarkers are needed. Because protein structure reflects function, we tested whether global, in situ analysis of protein structural changes provides insight into PD pathophysiology and could inform a new concept of s...

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Veröffentlicht in:	Nature structural & molecular biology 2022-10, Vol.29 (10), p.978-989
Hauptverfasser:	Mackmull, Marie-Therese, Nagel, Luise, Sesterhenn, Fabian, Muntel, Jan, Grossbach, Jan, Stalder, Patrick, Bruderer, Roland, Reiter, Lukas, van de Berg, Wilma D. J., de Souza, Natalie, Beyer, Andreas, Picotti, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/337/475 631/80/470/2284 692/699 82/58 alpha-Synuclein - metabolism Biochemistry Biological Microscopy Biomarkers Biomedical and Life Sciences Cerebrospinal fluid Humans Life Sciences Mass spectrometry Mass spectroscopy Membrane Biology Movement disorders Neurodegenerative Diseases Parkinson Disease Parkinson's disease Protein Structure Proteins Proteolysis Proteome - metabolism Proteomes Structure-function relationships Synuclein Variability
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