Aqueous extract of Polygonatum sibiricum ameliorates glucose and lipid metabolism via PI3K/AKT signaling pathway in high‐fat diet and streptozotocin‐induced diabetic mice

This study was aimed to investigate the protective effects and elucidate the mechanisms of aqueous extract of Polygonatum sibiricum (PSAE) on glucolipid metabolism during the development of type 2 diabetes (T2DM). C57BL/6J mice fed with 60% high‐fat diet (HFD) combined with streptozotocin (STZ) inje...

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Veröffentlicht in:	Journal of food biochemistry 2022-12, Vol.46 (12), p.e14402-n/a
Hauptverfasser:	Wang, Guangjun, Liu, Zhengxiang, Liang, Di, Yu, Jinchuan, Wang, Ting, Zhou, Fuding, Chen, Wenjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose Cholesterol diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - metabolism Diet, High-Fat - adverse effects Glucose - metabolism glucose and lipid metabolism Lipid Metabolism Mice Mice, Inbred C57BL Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT signaling pathway Polygonatum - metabolism Polygonatum sibiricum Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Streptozocin Triglycerides
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