Acute kidney injury due to antimicrobial therapy

One of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal re...

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Veröffentlicht in:Vnitřní lékar̆stvĭ 2022-10, Vol.68 (4), p.227-233
Hauptverfasser: Klementa, Viktor, Petejová, Naděžda, Zadražil, Josef, Horák, Pavel, Prošková, Jitka, Klementová, Olga
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container_issue 4
container_start_page 227
container_title Vnitřní lékar̆stvĭ
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creator Klementa, Viktor
Petejová, Naděžda
Zadražil, Josef
Horák, Pavel
Prošková, Jitka
Klementová, Olga
description One of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal replacement therapy. Several mechanisms have been described, although the most common are acute interstitial nephritis, acute tubular necrosis, crystalic nephropathy or proximal/distal tubulopathy with electrolyte abnormalities. General risk factors for antimicrobial-induced AKI include pre-existing chronic kidney disease and concomitant use of drugs with nephrotoxic potential. Prevention and early recognition of AKI are the standard approach to mitigate AKI and avoid morbidity.
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subjects Acute Kidney Injury - etiology
Anti-Bacterial Agents - adverse effects
Electrolytes - adverse effects
Humans
Kidney
Nephritis, Interstitial - chemically induced
Nephritis, Interstitial - complications
Renal Insufficiency, Chronic - complications
title Acute kidney injury due to antimicrobial therapy
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