Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells

Piper longum L., an herbal medicine used in India and other Asian countries, is prescribed routinely for a range of diseases, including tumor. Piperlongumine, a natural product isolated from Piper longum L., has received widespread attention due to its various pharmacological activities, such as ant...

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Veröffentlicht in:	Journal of ethnopharmacology 2023-01, Vol.301, p.115815-115815, Article 115815
Hauptverfasser:	Lan, Xiaoying, Hu, Min, Jiang, Liling, Wang, Jiamin, Meng, Yi, Chen, Xinmei, Liu, Aochu, Ding, Wa, Zhang, Haichuan, Zhou, Huan, Liu, Bingyuan, Peng, Guanjie, Liao, Siyan, Chen, Xin, Liu, Jinbao, Shi, Xianping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Bcr-abl Biological Products - therapeutic use Cell Line, Tumor Cell Proliferation CML Deubiquitinating Enzymes - therapeutic use Drug Resistance, Neoplasm Fusion Proteins, bcr-abl - genetics Humans Imatinib Mesylate - pharmacology Imatinib Mesylate - therapeutic use Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Mice Piperlongumine Proteasome Proteasome Endopeptidase Complex - metabolism Ubiquitin Thiolesterase - therapeutic use UCHL5 USP14
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